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Search results “Humanized mice microbiota and obesity”
Human gut microbes slim mice
 
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The mix of microbes living inside the gut can protect against obesity, but a healthy diet is critical, according to Washington University School of Medicine scientists who transplanted intestinal microbes from obese and lean twins into mice and fed the animals different diets. Animation by Vanessa Ridaura and Victor Ridaura. https://source.wustl.edu/2013/09/altering-mix-of-gut-microbes-prevents-obesity-but-diet-remains-key-factor/
Microbiome and Obesity - Martin Blaser
 
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July 24-26, 2013 - Human Microbiome Science: Vision for the Future More: http://www.genome.gov/27554404
Microbiome: Gut Bugs and You | Warren Peters | TEDxLaSierraUniversity
 
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Can gut bugs change the world? Join Warren Peters on a journey into understanding your microbiome and the new discoveries changing the way we understand diabetes, obesity, Alzheimer's disease, autism, and our everyday health and wellness. If asked, he will tell you that the first part of his medical career was in general surgery, where “if something is wrong with you, I will cut it out." The next was dedicated to lifestyle and natural medicines, where “if something is wrong with you, just try harder." And finally, the last part is dedicated to the molecular and genetic basis of obesity, where "if something is wrong with you, it is the fault of your parents and the changing environment." Within these three perspectives, reside the virtues of common sense and wisdom. He obtained his medical degree from Loma Linda University, his surgical training at the Mason Clinic in Seattle Washington, and, his Master’s degree in biostatistics and epidemiology from Loma Linda University. He is privileged to travel and lecture nationally and internationally on topics of nutrition, wholeness, and wellness. He has practiced surgical care, wholistic care, and, primary care in Washington, Maryland, Virginia, and California. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx
Views: 246187 TEDx Talks
Antibiotic Exposure, The Microbiome and Obesity
 
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A number of variables can cause signficant changes in the human microbiome early in life including birth method and antibiotic exposure. Understanding these shifts is important because new research suggests that shifts in the microbiome of infants could make them more prone to gain weight as adults. Participants will discuss variables involved in the development of the infant microbiome and how it affects adult metabolism and body composition in mouse models. Laura Cox, NYU Langone Medical Center Elizabeth Costello, Stanford University School of Medicine
How the Gut Microbiome affects the Brain and Mind
 
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Get 10% off any purchase here: http://squarespace.com/WIL ▲Patreon: https://www.patreon.com/WILearned ▲Twitter: https://twitter.com/jeverettlearned The gut microbiota is a huge topic and has some very significant implications for health and nutrition. Here I've explained just a tiny bit of the research. A pdf with a transcript for the video and links to sources can be found here: https://www.patreon.com/posts/17115405 ________ Books: "The Good Gut" by Justin and Erica Sonnenburg - http://amzn.to/2ETThV2 "Missing Microbes" By Martin Blaser - http://amzn.to/2Hu43jh "Brain Maker" By David Perlmutter - http://amzn.to/2sF5EiO (Not mentioned in the video, but another good book on the subject) Will have the transcript with links up soon Featured Music: Broke for Free - Meiei Chris Zabriskie - Mario Bava Sleeps in a Little Later than he expected to Broke for Free - Breakfast with Tiffany Chris Zabriskie - Divider Kevin MacLeod - Rollin at 5 For Business inquiries: [email protected]
Views: 650588 What I've Learned
Obesity, The Microbiome And "Alexander Microbes" [Functional Forum, James Maskell]
 
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http://goevomed.com/ Dr. Leo Galland discusses the human microbiome, and the importance of “Alexander Microbes” in combatting obesity in this video segment from the May 2015 Functional Forum. http://goevomed.com/hc Check out our August Functional Forum episode; a collaboration with the Institute for Functional Medicine. ---------------------------------------------------------------------------------- Filmed on location at the IFM’s Annual International Conference in May 2015, this Forum focused on not only the emerging “Omics” Revolution, but also the implications of that new understanding for patient care. From emerging mainstream TV stars to an update from Mark Hyman, MD about the Cleveland Clinic, this episode features some of the big names and rising stars in Functional Medicine, especially those innovating business models and showing very clearly the “Future of Functional”. This 90 minute show also features an extended session with George Slavich, PhD, whose talk was one the highlights of the conference looking at an emerging field: Social Genomics. https://www.functionalmedicine.org/conference.aspx?id=2972&cid=116&section=purchase http://youtu.be/q9vkR9xdoRU GoEvoMed
Views: 3097 Functional Forum
5 Reasons Why We’re Gaining More Weight Than Our Ancestors
 
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Along with the extraneous weight come the associated chronic diseases: diabetes, heart disease, cancer, and immune system dysfunction, to name the worst. When it comes to losing weight, there’s more to the equation than the number of calories you eat versus how many you burn. Our bodies are affected by environmental and lifestyle factors that must be considered. 1.Environment We are surrounded by human-made chemicals. They’re in our food, water, air, packaging, building materials, and personal care and household products. As the effects of these chemicals are studied, science is finding that many of them seriously mess up human physiology. Many chemicals (called obesogens) are known to cause weight gain and a resistance to weight-loss by disrupting the endocrine system. 2.Food Emulsifiers, coloring, preservatives, flavoring, and pesticidesin and on our food are causing inflammation, illness, and disease. The more a food is processed, the less nutritional valueit retains. Even fresh produce is questionable: the use of chemical-fertilizers and herbicides, along with genetic modification and varietal reduction, are detracting from inherent nutrition of vegetables and fruits. One example is triflumizole (TFZ), a common fungicide sprayed on food crops. It has been shown to cause weight-gain in mice and to put their fetuses at significantly higher risk for developing obesity than mice not exposed to TFZ. 3.Prescription Drugs We’re a drug culture. Almost half of us are taking at least one prescription. Over 23% are taking three or more on a regular basis. In 2016, the Centers for Disease Control and Prevention reported that over 75% of doctor visits resulted in patients leaving with a prescription. 4.Gut Microbiome The modern Western diet is killing our guts. The majority of our immune-system lives in our gastrointestinal tract; it’s packed with friendly bacteria that break down food, destroy harmful-bacteria and other micro-organisms, promote waste elimination, and more. Chemical-laden and nutrient-poor foods discourage pre- and pro-biotic bacteria and that’s directly affecting our health. Antibiotic medications kill both harmful and health-critical gastrointestinal microflora; their overuse and misuse have led to antibiotic resistance. These factors throw our internal ecosystems out of whack. The consequences include changes to metabolism, hormone-imbalance, and systemic inflammation—all contributors to obesity. 5.Chronic Stress Everyone has stress in their lives; not only is it normal, it’s necessary for survival. Chronic stress, however, potentiates a whole host of health problems, including weight-gain. Stress hormones such as cortisol initiate a chain reaction that puts your body in survival-mode, regulating blood-pressure and blood-sugar, heart-rate, hunger, other hormones, and overall metabolism. There is a definite link between chronic-stress and obesity. How to Fight Back Knowing the cause of a problem helps a great deal toward finding solutions. Directly addressing culprits that cause us to gain-weight will help us to lose excess and keep it off. • Eat whole foods, keeping processed foods to a minimum. • Ensure you get regular adequate, good-quality sleep. • Find constructive, healthy ways to manage stress. • Cut out added and refined sugars • Keep up or increase your aerobic and resistance training exercise program.
Views: 1308 Natural Solution
Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance
 
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Scientists from the NIH’s National Institute of Diabetes and Digestive and Kidney Diseases led research finding that transferring the gut microbes from wild mice to laboratory mice promoted fitness and significantly improved responses to an otherwise lethal flu virus infection and to colorectal cancer. By making lab mice more closely mirror real-world mice, the approach may improve the odds of success as research moves from mouse to man. The method could also help advance studies in metabolism, behavior, and endocrinology. The results published in Cell: www.cell.com/cell/fulltext/S0092-8674(17)31065-6
Microbiome and Obesity
 
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Microbiome
Views: 228 EmergingScience
The Gut Microbiome in Health and Disease | Susan Tuddenham, M.D., M.P.H.
 
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Susan Tuddenham discusses the role of the intestinal microbiome in human health and disease. To learn more about this event and to access slides for this presentation please visit: http://www.hopkinsmedicine.org/institute_basic_biomedical_sciences/news_events/2017_The_Frenemy_Within.html
Human Derived Gut Microbiota Modulates Colonic Secretion in Mice …  – Bhattarai et al. (2017)
 
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Serotonin (5-hydroxytryptamine, 5-HT), an important neurotransmitter and a paracrine messenger in the gastrointestinal (GI) tract, regulates intestinal secretion by its action primarily on 5-HT3 and 5-HT4 receptors. Recent studies highlight the role of gut microbiota in 5-HT biosynthesis. In this study we determine if human-derived gut microbiota affect host secretory response to 5-HT and 5-HT receptor expression. We used proximal colonic mucosa-submucosa preparation from age matched Swiss Webster germ free (GF) and humanized (HM; ex-GF colonized with human gut microbiota) mice. 5-HT evoked a significantly greater increase in short circuit current (ΔIsc) in GF compared to HM mice. (Full article: https://doi.org/10.1152/ajpgi.00448.2016)
MICROBIOTA, ANTIBIOTICS AND OBESITY
 
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MICROBIOTA, ANTIBIOTICS AND OBESITY
Views: 105 Massimo Zappia
Keynote speaker: Listen to the gut: Lessons for IBD from the microbiome
 
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Earn CME credit for this activity: https://naccme.com/program/7318 In this Keynote presentation from the Clinical Track at the 2018 Advances in Inflammatory Bowel Diseases, Dr. Eugene B. Chang discusses the microbiome and its relation to inflammatory bowel disease (IBD). © 2018 Imedex, an HMP Company
Views: 1223 ImedexCME
What is the microbiome?
 
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Our human cells are outnumbered by microbial cells - so are we more microbe than human? Subscribe to Nourishable at https://www.youtube.com/c/Nourishable Follow Nourishable on twitter, facebook and instagram to stay up to date on all things nutrition. https://twitter.com/nourishable fb.me/nourishable.tv https://www.instagram.com/nourishable/ Hosting, Research, Writing & Post-Production by Lara Hyde, PhD http://www.nourishable.tv Music & Video Production by Robbie Hyde https://www.youtube.com/user/chedderchowder Motion Graphics by Jay Purugganan https://www.c9studio.com/WP/ Script with in-text citations https://goo.gl/C3qRMW Images: personal collection, shutterstock, pixabay, www.vecteezy.com/ by veernavya, lavarmsg, ayaankabir, seabranddesign, momentbloom The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this video is for general information purposes only. References Bianconi et al. 2013. “An Estimation of the Number of Cells in the Human Body.” Annals of Human Biology 40 (6): 463–71. Butel, M-J. 2014. “Probiotics, Gut Microbiota and Health.” Médecine et Maladies Infectieuses 44 (1): 1–8. Chen et al. 2017. “The Microbiota Continuum along the Female Reproductive Tract and Its Relation to Uterine-Related Diseases.” Nature Communications 8 (1): 875. David et al. 2014. “Diet Rapidly and Reproducibly Alters the Human Gut Microbiome.” Nature 505 (7484): 559–63. Dinan et al. 2017. “The Microbiome-Gut-Brain Axis in Health and Disease.” Gastroenterology Clinics of North America 46 (1): 77–89. “Federal Engagement in Antimicrobial Resistance | Antibiotic/Antimicrobial Resistance | CDC.” https://www.cdc.gov/drugresistance/federal-engagement-in-ar/index.html#tabs-835289-5. Flint et al. 2015. “Links between Diet, Gut Microbiota Composition and Gut Metabolism.” The Proceedings of the Nutrition Society 74 (1): 13–22. Hansen et al. 2014. “Impact of the Gut Microbiota on Rodent Models of Human Disease.” World Journal of Gastroenterology: WJG 20 (47): 17727–36. “Human Microbiome Project - Public Health Relevance | NIH Common Fund.” n.d. Accessed May 22, 2018. https://commonfund.nih.gov/hmp/public. Jeffery et al. 2013. “Diet-Microbiota Interactions and Their Implications for Healthy Living.” Nutrients 5 (1): 234–52. Jenkins et al. 2016. “Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis.” Nutrients 8 (1). https://doi.org/10.3390/nu8010056. LeBlanc et al. 2013. “Bacteria as Vitamin Suppliers to Their Host: A Gut Microbiota Perspective.” Current Opinion in Biotechnology 24 (2): 160–68. Lloyd-Price et al. 2017. “Strains, Functions and Dynamics in the Expanded Human Microbiome Project.” Nature 550 (7674): 61–66. Montoya-Williams et al. 2018. “The Neonatal Microbiome and Its Partial Role in Mediating the Association between Birth by Cesarean Section and Adverse Pediatric Outcomes.” Neonatology 114 (2): 103–11. O’Mahony et al. 2015. “Serotonin, Tryptophan Metabolism and the Brain-Gut-Microbiome Axis.” Behavioural Brain Research 277 (January): 32–48. Pascale et al. 2018. “Microbiota and Metabolic Diseases.” Endocrine. https://doi.org/10.1007/s12020-018-1605-5. Perez-Muñoz et al. 2017. “A Critical Assessment of the ‘sterile Womb’ and ‘in Utero Colonization’ Hypotheses: Implications for Research on the Pioneer Infant Microbiome.” Microbiome 5 (1). https://doi.org/10.1186/s40168-017-0268-4. Pimentel et al. 2013. “Gas and the Microbiome.” Current Gastroenterology Reports 15 (12). https://doi.org/10.1007/s11894-013-0356-y. Ridaura et al. 2013. “Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice.” Science 341 (6150): 1241214. Sender et al. 2016. “Revised Estimates for the Number of Human and Bacteria Cells in the Body.” PLoS Biology 14 (8): e1002533. Tamburini et al. 2016. “The Microbiome in Early Life: Implications for Health Outcomes.” Nature Medicine 22 (7): 713–22. Theriot & Young. 2015. “Interactions Between the Gastrointestinal Microbiome and Clostridium Difficile.” Annual Review of Microbiology 69 (1): 445–61. Turnbaugh et al. 2009. “A Core Gut Microbiome in Obese and Lean Twins.” Nature 457 (7228): 480–84. Turnbaugh et al. 2006. “An Obesity-Associated Gut Microbiome with Increased Capacity for Energy Harvest.” Nature 444 (7122): 1027–31. Versini et al. 2015. “Unraveling the Hygiene Hypothesis of Helminthes and Autoimmunity: Origins, Pathophysiology, and Clinical Applications.” BMC Medicine 13 (April): 81. Vrieze et al. 2012. “Transfer of Intestinal Microbiota from Lean Donors Increases Insulin Sensitivity in Individuals with Metabolic Syndrome.” Gastroenterology 143 (4): 913–16.e7. Yano et al. 2015. “Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis.” Cell 161 (2): 264–76.
Views: 330 Nourishable
Pediatric Gut Microbiota, Antibiotics, and Obesity
 
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References: 1. Dietitians of Canada. Gastrointestinal System – Microbiota. In: Practice-based Evidence in Nutrition [PEN]. 2016 July 27 [cited 2016 Dec 1]. Available from: http://www.pennutrition.com.ezproxy.library.ubc.ca/KnowledgePathway.aspx?kpid=24357&trid=25391&trcatid=38. Access only by subscription. 2. Canadian Society of Intestinal Research. Gut Bacteria: Manipulating body fat, mood, and IBS by mixing up the microorganisms in your gut. Inside Tract. 2014;(190), 20-21. 3.Ridaura V, Faith J, Rey F, Cheng U, Duncan A, Gordon J, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 2013 Sep 6, [cited November 3, 2016]; 341(6150): 1241214. Available from: http://science.sciencemag.org.ezproxy.library.ubc.ca/content/341/6150/1241214.full 4. Koleva P, Bridgman S, Kozyrskyj, A. The infant gut microbiome: evidence for obesity risk and dietary intervention. Nutrients. 2015 March 31 [cited December 1, 2016]; 7(4): 2237-2260. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425142/  5. Trasande L, Blustein J, Liu M, Corwin E, Cox LM, Blaser MJ. Infant antibiotic exposures and early-life body mass. International journal of obesity. 2013 Jan 1 [cited November 3, 2016];37(1):16-23. 6. Korpela K, Salonen A, Virta LJ, Kekkonen RA, Forslund K, Bork P, de Vos WM. Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children. Nature Communications. 26 Jan 2016. [cited December 1, 2016];10410. Available from: http://www.nature.com/articles/ncomms10410 7. Schwartz BS, Pollak J, Bailey-Davis L, Hirsch AG, Cosgrove SE, Nau C, Kress AM, Glass TA, Bandeen-Roche K. Antibiotic use and childhood body mass index trajectory. International Journal of Obesity. 2016 Apr 1 [cited November 3, 2016];40(4):615-21.
Views: 592 Claudia Wong
Podcast #177 - Dr. Grace Liu: Fixing the Gut Microbiome with Resistant Starch and Probiotics
 
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Dr. Grace Liu is renowned for the information she publishes on the blog, Animal Pharm, under the name “Dr. BG”. She is a Food and Nutritional Scientist and Functional Medicine Practitioner with a doctorate in Pharmacology, and one of the most knowledgeable people on the hot button topics of resistant starch (RS) and its effects on the health of the gut microbiome. She uses her expertise in the pharmaceutical world to explore the various scientific, nutritional, and pharmacological ins and outs of optimal health. Why you should listen – Hal comes on Bulletproof Radio to discuss the difference between resistant starch and regular starch, how resistant starch works in the body, how to prioritize the different testing methods for determining gut health, and the things you can do to start fixing your gut immediately. Enjoy the show! For more info & to follow Dr. Grace: Dr. BG Animal Pharm Blog - http://drbganimalpharm.blogspot.com/ The Gut Guardians Podcast – Restore the Flora! - http://restoretheflora.com/podcast-2/ Twitter - @Gut_Goddess - https://twitter.com/Gut_Goddess Resources: The Definitive Guide to Resistant Starch (Mark’s Daily Apple) - http://www.marksdailyapple.com/the-definitive-guide-to-resistant-starch/ Gut bacteria’s fatty acid (butyrate) boosts immune system, reducing inflammation - http://www.medicalnewstoday.com/articles/268786.php Glycemix Index (GI) - http://www.glycemicindex.com/about.php Starch polysaccharides in human nutrition (Critical Reviews in Food Science and Nutrition) - http://www.ncbi.nlm.nih.gov/pubmed/22747080 FODMAPS (Chris Kresser) - http://chriskresser.com/fodmaps-could-common-foods-be-harming-your-digestive-health Intestinal Dysbiosis - http://altmedrev.com/publications/9/2/180.pdf Bacteroides - https://microbewiki.kenyon.edu/index.php/Bacteroides Conjugated linoleic acid for reducing fat mass (American Journal of Clinical Nutrition) - http://ajcn.nutrition.org/content/85/5/1203.full Intestinal microbiota in aged mice is modulated by dietary resistant starch (FEMS Microbiology Ecology) - http://www.ncbi.nlm.nih.gov/pubmed/22909308 uBiome - http://ubiome.com/ Genova 2200 GI Testing - https://www.gdx.net/core/interpretive-guides/GI-Effects-IG.pdf American Gut - http://humanfoodproject.com/americangut/ Gastroesophageal Reflux Disease (GERD) - http://www.nlm.nih.gov/medlineplus/gerd.html Efficacy of increased resistant starch consumption in human type 2 diabetes (Endocrine Connections) - http://www.ncbi.nlm.nih.gov/pubmed/24671124 Yacon syrup: beneficial effects on obesity and insulin resistance in humans (Clinical Nutrition) - http://www.ncbi.nlm.nih.gov/pubmed/19254816 Inulin - http://www.ncbi.nlm.nih.gov/pubmed/24969566 Fructooligosaccharides (Journal of Physiology and Biochemistry) - http://www.ncbi.nlm.nih.gov/pubmed/20119826 Prevotella - https://microbewiki.kenyon.edu/index.php/Prevotella Bifidobacterium - https://microbewiki.kenyon.edu/index.php/Bifidobacterium Oxalic Acid - http://pubchem.ncbi.nlm.nih.gov/compound/oxalic_acid Trypsin inhibitors - http://en.wikipedia.org/wiki/Trypsin_inhibitor Cecum - http://en.wikipedia.org/wiki/Cecum Curcumin - http://www.ncbi.nlm.nih.gov/pubmed/17569205 AMP Kinase (AMPK) - http://en.wikipedia.org/wiki/AMP-activated_protein_kinase Telomeres - http://www4.utsouthwestern.edu/cellbio/shay-wright/intro/facts/sw_facts.html Clostridia - http://www.ncbi.nlm.nih.gov/books/NBK8219/ Betaine HCl - http://amzn.to/1u0mzQD Lactobacillus - http://www.nlm.nih.gov/medlineplus/druginfo/natural/790.html Helicobacter Pylori (Mayo Clinic) - http://www.mayoclinic.org/diseases-conditions/h-pylori/basics/definition/con-20030903 Neurosciences NeuroScreen Essential Neurotransmitter Saliva Test - https://www.neurorelief.com/index.php?p=testDet&testID=238&TestPanelName=NeuroScreen Essential NutrEval FMV Urine Organic Acid Test - https://www.gdx.net/product/nutreval-fm-nutritional-test-blood-urine Akkermansia - http://en.wikipedia.org/wiki/Akkermansia_muciniphila Microflora in centenarians and young subjects (Journal of Clinical Gastroenterology) - http://www.ncbi.nlm.nih.gov/pubmed/22955365 Ox Bile - http://amzn.to/1yofh0s AOR Probiotic-3 - http://amzn.to/1vUySCd Align GI - http://amzn.to/1yxjZbd Garden of Life Primal Defense Ultra - http://amzn.to/1FUqHIA Prescript Assist - http://amzn.to/1FUqAfZ Bulletproof: Uncovering Resistant Starch with Dr. Grace Liu – Podcast #117 - http://bit.ly/1yodubZ Bulletproof Diet Book - http://www.orderbulletproofdietbook.com/ Is there such a thing as Bulletproof Resistant Starch? - http://bit.ly/1vUxu2x The Kale Shake is Awesome – So Upgrade It - http://bit.ly/1rqt2YG Donna Gates on Body Ecology – Podcast #122 - http://bit.ly/12IQl75
Views: 26594 Bulletproof
Treating the Microbiota in Obesity
 
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A study was just published in which a group of women received a microbiota treatment, with prebiotics, while having their microbiota’s and weight tracked. Did the microbiota shift? Did this cause weight loss? Let’s review the findings. Want more info? Email us at [email protected], call at (800) 335-7009 and visit me at http://www.DrRuscio.com. For your free e-book on gut health, click here: http://drruscio.com/youtube-subscription/ Dr. Ruscio is your leading functional and integrative doctor specializing in gut related disorders such as SIBO, leaky gut, Celiac, IBS and in thyroid disorders such as hypothyroid and hyperthyroid. For more information on how to become a patient, please contact our office. Serving the San Francisco bay area and distance patients via phone and Skype.
Gut microbiota and obesity, what comes first?
 
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Dr. Thomas Greiner explains that the gut microbiota is influenced by your genes, who you're born from and you diet. However the gut microbiota is different between obese and lean patients. In the future studies may discover a right mixture of the bacteria and prevent obesity.
Obesity and Microbiome
 
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Mygerm helps you to choose the right Probiotics! You will get more information about microbiome and probiotics. Please come and check out our recommendations of probiotic products. www.mygerm.com
Views: 717 MyGerm
Microbiomes
 
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A very brief review of microbiomes, and three key studies related to obesity in mice.
Views: 427 BIS 2C- UC Davis
Bacteria From Obese People Make Mice Fatter
 
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According to data from a recent study by researchers at Washington University in St. Louis, Missouri, germs transplanted from obese people made mice gain weight. According to data from a recent study by researchers at Washington University in St. Louis, Missouri, germs transplanted from obese people made mice gain weight. For the study, researchers took fecal samples from pairs of twins that had one skinny twin and one obese twin, to see how they would affect the mice who are identical and were raised to have no bacteria produced in their stomachs. When researchers fed the fecal samples from the digestive tract of the obese twin to the lab mice, it made them fatter. The researchers also fed fecal samples from the stomachs of the skinny twin to mice and found that the bacteria in it actually prevented them from gaining weight. It is common for mice to eat each other's feces and exchange bacterial microbes but the germs from the skinny twin out-competed the germs from the obese twin. Jeffrey Gordon, the senior investigator of the study said: "Eating a healthy diet encourages microbes associated with leanness to quickly become incorporated into the gut. But a diet high in saturated fat and low in fruits and vegetables thwarts the invasion of microbes associated with leanness." The results of the study might be used to come up with a probiotic bacteria that can be taken to manage weight loss.
Views: 1940 GeoBeats News
The Microbiome: Vital Cells of Existence
 
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For every cell in your body, there’s another tiny single-celled creature that also calls your body home. Far from being germs we should eradicate, these ancient friends allow us to digest food, breathe air, and fight off disease. They were here long before us and will undoubtedly remain long after we’re gone. They are our microbiome, and after eons of cohabitation, we are finally getting to know one another better. Of course, we aren’t always the best of neighbors. Autoimmune diseases, allergies, depression, and Alzheimer’s may be diseases of an unhappy microbiome. PARTICIPANTS: Martin Blaser, Jo Handelsman, Rob Knight, and David Relman MODERATOR: Dr. Emily Senay MORE INFO ABOUT THE PROGRAM AND PARTICIPANTS: https://www.worldsciencefestival.com/programs/wsf18_b_09/ This program is part of the Big Ideas Series, made possible with support from the John Templeton Foundation. - Subscribe to our YouTube Channel and ring the "bell" for all the latest from WSF - Visit our Website: http://www.worldsciencefestival.com/ - Like us on Facebook: https://www.facebook.com/worldsciencefestival/ - Follow us on Twitter: https://twitter.com/WorldSciFest TOPICS: - Program introduction 03:12 - Participant introductions 03:40 - When do we acquire our microbiome? 04:50 - Connection between the microbiome and our immune system 07:00 - Using mice to study the microbiome 07:45 - When does your microbiome stabilize? 08:55 - What is the Human Microbiome Project? 11:20 - How unique is each person's microbiome? 14:02 - Mapping the microbiome on different areas of the body 14:54 - The effects of extensive antibiotic use on the microbiome and cause of modern diseases 15:19 - Are the microbes in dirt good for us? 18:01 - Rates of asthma in the Amish and Hutterites 19:50 - Hygiene hypothesis 21:20 - Antibiotic use and the rise of obesity in the US 23:25 - Obesity and the microbiome 25:05 - How do changes in the microbiome get passed from generation to generation? 29:30 - C. difficile and fecal transplants 33:20 - Can fecal transplants be used to treat other diseases? 37:57 - Connection between the gut and the brain 42:00 - Can the microbiome cause depression? 43:20 - How do you study depression in mice? 46:25 - Is there a strong association between what is happening in the gut and behavior? 49:35 - Is the microbiome connected to autism? 50:51 - How do the microbiomes of hunter-gatherers living in primitive conditions compared to people with high exposure to antibiotics? 52:45 - Is it possible that we'll never recapture our full ancestral microbiota diversity? 54:15 - How can we keep our microbiome happy and healthy? 56:51 - The role of the microbiome in precision medicine and drug efficacy 59:15 - Do probiotics really work? 1:03:04 PROGRAM CREDITS: - Produced by Nils Kongshaug - Associate Produced by Laura Dattaro - Opening film produced / directed by Vin Liota - Music provided by APM - Additional images and footage provided by: Getty Images, Shutterstock, Videoblocks, Kishony Lab at Harvard Medical School and Technion--Israel Institute of Technology, Mazmanian Lab at California Institute of Technology, CDC This program was recorded live at the 2018 World Science Festival and has been edited and condensed for YouTube.
Views: 17450 World Science Festival
Human Science (Part 1) - The Gut Brain Axis, Microbiome & the power of Probiotics
 
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Fascinating new research tells us that our gut exerts an influence on the brain, affecting our mood, hormonal balance and obesity levels. Ps. Big welcome to all new subscribers! For more research, here's a starting point: https://www.psychologytoday.com/blog/inner-source/201411/the-gut-microbiome-anxiety-and-depression-6-steps-take Also: http://www.drperlmutter.com/research-probiotic-intervention-affects-mood/ Sneaky Snitch Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 3.0 License http://creativecommons.org/licenses/by/3.0/ You can support this channel here: https://www.patreon.com/infognostica
Views: 41944 Infognostica
The microbiota as instructor and arbiter of immune responses in health and disease
 
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The microbiota as instructor and arbiter of immune responses in health and disease Air date: Wednesday, February 22, 2017, 3:00:00 PM Category: WALS - Wednesday Afternoon Lectures Runtime: 01:07:59 Description: NIH Director's Wednesday Afternoon Lecture Series The vertebrate intestinal tract is colonized by hundreds of species of bacteria that outnumber the total cells in the host, yet must be compartmentalized and tolerated to prevent invasive growth and harmful inflammatory responses. A key function of commensal microbes is to contribute to the adaptive immune repertoire and to diverse lymphocyte effector functions. T cell responses against non-invasive commensals contribute to shaping the repertoire of effector/memory and regulatory T cells. How T cells elicited by commensal bacteria can influence autoimmunity is a central question that remains unsolved. The Littman Lab studies the antigenic specificity of microbiota-induced T cells and the mechanisms by which their functions are acquired upon interaction with distinct commensal species. His lab finds that Th17 cells, which are central to mucosal barrier defense but also participate in autoimmune disease, are induced by specific constituents of the microbiota, and acquire effector function only after additional exposure to endogenous adjuvants, such as the serum amyloid A proteins. The lab's studies in mice are not only relevant for human autoimmune diseases, many of which have Th17 cell involvement, but may also provide insights into how commensal microbe-specific T cell responses could be harnessed for mucosal vaccination and cancer immunotherapy. For more information go to https://oir.nih.gov/wals/2016-2017 Author: Dan R. Littman, M.D., Ph.D., Investigator, Howard Hughes Medical Institute; Kimmel Professor of Molecular Immunology at New York University School of Medicine Permanent link: https://videocast.nih.gov/launch.asp?22148
Views: 6390 nihvcast
Obesity and the Microbiota
 
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3 Roundtable Symposia from ASPEN Clinical Nutrition Week 2015: Microbiome
the human microbiome 1
 
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https://www.edx.org/course/nutrition-health-human-microbiome-wageningenx-nutr104x
Views: 76 invisibleocean
Lora Hooper (UT Southwestern) 1: Mammalian gut microbiota: Mammals and their symbiotic gut microbes
 
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https://www.ibiology.org/immunology/gut-microbiota/ Overview: Dr. Hooper studies how the gut microbiota changes during illness or disease and how it influences our ability to fight infections. In part 2, Hooper explains how a healthy gut microbes induce a host protein called RegIIIγ which helps to protect the host from infection by pathogenic gram-positive bacteria. Detailed description: In this lecture, Dr. Hooper introduces us to the fascinating world of human microbiota; the microorganisms that live within our bodies. Although we may think that most bacteria are harmful, Hooper provides ample evidence that symbiotic gut microbes are important to good human health. Her lab is interested in understanding how the microbiota changes during illness or disease and how it influences our ability to fight infections. Using germ-free mice, they were able to demonstrate that a healthy microbiota can shape development of the host immune system and provide protection against dangerous infections like salmonella. In the second part of her talk, Hooper explains how the balance of organisms in the microbiota is maintained. By comparing DNA microarray data from normal mice and germ-free mice, Hooper’s lab was able to look for genes induced by the microbiota. They identified RegIIIγ, an important protein involved in the protection against pathogenic bacteria. They showed that RegIIIγ forms pore complexes in the membranes of gram-positive bacteria and kills them. In mice and humans, the intestinal epithelium is coated with a layer of mucus. Typically, there is a gap between gut bacteria, which are found in the outer part of the mucus layer, and the epithelial cells. Hooper’s lab showed that RegIIIγ helps to maintain this gap by preventing gram-positive bacteria from colonizing the intestinal epithelial surface. This, in turn, prevents infection of the host. Speaker Biography: Although she always was interested in science, Lora Hooper’s love for biology started after taking an introductory class at Rhodes College in Memphis, TN where she was an undergraduate. Hooper continued her graduate education in the Molecular Cell Biology and Biochemistry Program at Washington University in St. Louis where she joined Dr. Jacques Baenziger's lab. For postdoctoral training, she stayed at Washington University, in the lab of Jeffrey Gordon, where she began her studies of the interaction between gut bacteria and host cells and discovered that bacteria have the capacity to modify carbohydrates important for cell signaling. Currently, Hooper is a Professor at The University of Texas Southwestern Medical Center and a Howard Hughes Medical Institute Investigator. She has established one of the handful of mouse facilities that have the capacity to breed germ-free mice. Using these mice, her lab explores the symbiotic relationship between a host and its microbiota with the aim of providing insight into human health. Hooper was a recipient of the Edith and Peter O’Donnell Awards in 2013 and in 2015 she was elected to the National Academy of Sciences.
Views: 7008 iBiology
Gut microbes - Could they help to prevent later obesity ?
 
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In this presentation Rob Knight explains that it is now possible to identify whether a person is lean or obese just by looking at the bacteria in the gut. However it is not the easiest way to see this, what is more interesting is that the human genome is also capable to tell if a person might become lean or obese in the future.
Gut reactions: host microbiome interactions in the intestine in health and disease
 
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Gut reactions: host microbiome interactions in the intestine in health and disease Air date: Wednesday, March 14, 2018, 3:00:00 PM Category: WALS - Wednesday Afternoon Lectures Runtime: 01:00:44 Description: NIH Director's Wednesday Afternoon Lecture Series The gastrointestinal tract is home to a large number and vast array of bacteria that play an important role in nutrition, immune-system development, and host defense. In inflammatory bowel disease there is a breakdown in this mutualistic relationship resulting in aberrant inflammatory responses to intestinal bacteria. Studies in model systems indicate that intestinal homeostasis is an active process involving a delicate balance between effector and immune suppressive pathways. For her presentation, Dr. Powrie will discuss bacterial pathways that promote intestinal homeostasis and host defense, and how these may be harnessed therapeutically. For more information go to https://oir.nih.gov/wals/2017-2018/ Author: Fiona Powrie, D. Phil., Professor; Director, Kennedy Institute of Rheumatology, University of Oxford Permanent link: https://videocast.nih.gov/launch.asp?23754
Views: 2628 nihvcast
PyData Tel Aviv Meetup: Machine Learning Applied to Mice Diet and Weight Gain - Daphna Rothchild
 
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PyData Tel Aviv Meetup #4 7 May 2017 Sponsored by Deep Learning Academy and hosted by Campus Tel Aviv https://www.meetup.com/PyData-Tel-Aviv/ Persistent microbiome alterations modulate the rate of post-dieting weight regain In tackling the obesity pandemic, significant efforts are devoted to the development of effective weight reduction strategies, yet many dieting individuals fail to maintain a long-term weight reduction, and instead undergo excessive weight regain cycles. The mechanisms driving recurrent post-dieting obesity remain largely elusive. Here we identify an intestinal microbiome signature that persists after successful dieting of obese mice, which contributes to faster weight regain and metabolic aberrations upon re-exposure to obesity-promoting conditions and transmits the accelerated weight regain phenotype upon inter-animal transfer. We develop a machine-learning algorithm that enables personalized microbiome-based prediction of the extent of post-dieting weight regain. Additionally, we find that the microbiome contributes to diminished post-dieting flavonoid levels and reduced energy expenditure, and demonstrate that flavonoid-based ‘post-biotic’ intervention ameliorates excessive secondary weight gain. Together, our data highlight a possible microbiome contribution to accelerated post-dieting weight regain, and suggest that microbiome-targeting approaches may help to diagnose and treat this common disorder. www.pydata.org PyData is an educational program of NumFOCUS, a 501(c)3 non-profit organization in the United States. PyData provides a forum for the international community of users and developers of data analysis tools to share ideas and learn from each other. The global PyData network promotes discussion of best practices, new approaches, and emerging technologies for data management, processing, analytics, and visualization. PyData communities approach data science using many languages, including (but not limited to) Python, Julia, and R. PyData conferences aim to be accessible and community-driven, with novice to advanced level presentations. PyData tutorials and talks bring attendees the latest project features along with cutting-edge use cases.
Views: 498 PyData
University of Maryland School of Medicine Researchers Identify Gut Bacteria Associated With Obesity
 
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Researchers at the University of Maryland School of Medicine have identified 26 species of bacteria in the human gut microbiota that appear to be linked to obesity and related metabolic complications. These include insulin resistance, high blood sugar levels, increased blood pressure and high cholesterol, known collectively as "the metabolic syndrome," which significantly increases an individual's risk of developing diabetes, cardiovascular disease and stroke. The results of the study, which analyzed data from the Old Order Amish in Lancaster County, PA, were published online on Aug. 15, 2012, in PLOS ONE, which is published by the Public Library of Science (PLOS). The study is the result of an ongoing collaboration between Claire M. Fraser, PhD, professor, Departments of Medicine and Microbiology & Immunology and director of the Institute for Genome Sciences (IGS) and Alan R. Shuldiner, MD, who is the John L. Whitehurst Professor of Medicine, associate dean for personalized medicine, and director of the Program in Personalized and Genomic Medicine. The collaboration is in connection with the NIH's Human Microbiome Project, which seeks to characterize microbial communities in the body. In this video, Dr. Shuldiner explains their research. Learn more: http://somvweb.som.umaryland.edu/absolutenm/templates/?a=2014
What gut ailments is faecal microbiotat transplants used to treat?
 
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Are miraculous poo transplants the future cure-all? Poo transplants or faecal microbiota transplants (FMTs) Yes, it’s exactly as it sounds. A poo transplant takes microbe-rich poo from a healthy person and puts it into someone else. It acts like a microbe reset. Research shows that giving mice brave poo creates brave mice, obese poo creates obese mice, and depressed poo creates depressed mice. These huge changes in behaviour and thinking raise fascinating questions: do your microbes make you who you are? Is there an ideal microbe mix? Or do our unique life experiences and DNA mean what’s best for me is not best for you? The jury is out as research and human trials continue, so be wary of media hype. Don’t try this at home. Dr Amy and Dr Chamara from St Vincent’s Hospital Melbourne, and transplant recipient Bobbie with her mum Carol. They talk frankly about all things poo transplant, from what ailments it is used for to how do you talk about it at a barbecue. To view the rest of the videos in the series go to the playlist here: https://www.youtube.com/watch?v=PLYprEkOyNs&list=PLDP58nenCzbSGmKU9wwKSy1NAAv2UwvK- Or visit the Museums Victoria Channel: https://www.youtube.com/channel/UC0t15MtzfDU1fH6MdhAL7KQ?view_as=subscriber
Views: 661 Museums Victoria
Utilizing Gnotobiotic Mice to Understand the Role of the Microbiome in Murine Disease Models
 
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The environmentally exposed surfaces of mammals, such as the skin, mouth, gut, and vagina, are colonized by a diverse ecosystem of microbes. Though many of these bacteria - particularly those of the distal gut - are considered symbiotic, the microbiome has the capacity to induce both pro- and anti- inflammatory responses. Accumulating evidence suggests that a properly balanced gut microbiome is crucial for a correctly functioning immune system, and that imbalances in the microbial community of the intestine are linked to a multitude of auto-inflammatory and auto-immune diseases. This symposium will discuss the roles of the microbiome in murine models of various inflammatory disease states, and the advantages to utilizing germ-free/gnotobiotic mice when probing disease models with a microbiome component.
Views: 366 Biomodels, LLC
03 ENG - Human Gut Microbiota - Onset and Shaping through life stages
 
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Moderator: Pr Henry COHEN (Uruguay) Speaker: Pr Luis BUSTOS FERNANDEZ (Argentina) Q&A
Gut Bacteria, Microbiome Project & Your Metabolism
 
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Download my free video course about gut bacteria and your metabolism here http://bellyfateffect.com/
Views: 5803 Mike Mutzel, MS
How did you hear about faecal microbiota transplants (poo transplants)?
 
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Are miraculous poo transplants the future cure-all? Poo transplants or faecal microbiota transplants (FMTs) Yes, it’s exactly as it sounds. A poo transplant takes microbe-rich poo from a healthy person and puts it into someone else. It acts like a microbe reset. Research shows that giving mice brave poo creates brave mice, obese poo creates obese mice, and depressed poo creates depressed mice. These huge changes in behaviour and thinking raise fascinating questions: do your microbes make you who you are? Is there an ideal microbe mix? Or do our unique life experiences and DNA mean what’s best for me is not best for you? The jury is out as research and human trials continue, so be wary of media hype. Don’t try this at home. Dr Amy and Dr Chamara from St Vincent’s Hospital Melbourne, and transplant recipient Bobbie with her mum Carol. They talk frankly about all things poo transplant, from what ailments it is used for to how do you talk about it at a barbecue. To view the rest of the videos in the series go to the playlist here: https://www.youtube.com/watch?v=PLYprEkOyNs&list=PLDP58nenCzbSGmKU9wwKSy1NAAv2UwvK- Or visit the Museums Victoria Channel: https://www.youtube.com/channel/UC0t15MtzfDU1fH6MdhAL7KQ?view_as=subscriber
Views: 174 Museums Victoria
Inflammation, dysbiosis and chronic disease
 
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Inflammation, dysbiosis and chronic disease Air date: Wednesday, March 18, 2015, 3:00:00 PM Category: WALS - Wednesday Afternoon Lectures Runtime: 01:11:52 Description: Wednesday Afternoon Lecture Series Dysregulation of the immune system and host-microbiota interaction has been associated with the development of a variety of inflammatory as well as metabolic diseases such as obesity and diabetes. Recent studies in Dr. Flavell's laboratory have elucidated the important function of inflammasomes as steady-state sensors and regulators of the gut microbiota. Mice with a disrupted inflammasome pathway have been shown to develop a colitogenic microbial community, which results in exacerbation of chemical-induced colitis and diet-induced steatohepatitis, obesity and type 2 diabetes. These disease phenotypes have been associated with dysbiosis resulting from the expansion of "pathobionts" which are believed to be causally driving pathogenesis. A key issue is to identify and isolate such problematic organisms. Dr. Flavell will discuss a new way that he and his colleagues have developed to identify and isolate such organisms from mice and humans. Using this approach, his lab has shown that predicted "pathobionts" from human patients with inflammatory bowel diseases (IBD) that they isolated by this approach can drive susceptibility to severe IBD in germ-free mice, whereas predicted harmless microbes from the same patients do not. These data suggest a significant involvement of such microbes in human disease. For more information go to http://wals.od.nih.gov Author: Richard A. Flavell, Ph.D. FRS, Yale School of Medicine Permanent link: http://videocast.nih.gov/launch.asp?18900
Views: 2771 nihvcast
Widely used food additive promotes colitis, obesity and metabolic syndrome
 
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* Please pass on to those with digestion concerns - Widely used food additive promotes colitis, obesity and metabolic syndrome, research shows The team fed mice two very commonly used emulsifiers, polysorbate 80 and carboxymethylcellulose, at doses seeking to model the broad consumption of the numerous emulsifiers that are incorporated into almost all processed foods. Such changes in bacteria triggered chronic colitis in mice genetically prone to this disorder, due to abnormal immune systems. In contrast, in mice with normal immune systems, emulsifiers induced low-grade or mild intestinal inflammation and metabolic syndrome, characterized by increased levels of food consumption, obesity, hyperglycemia and insulin resistance. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome Nature 519, 92–96 (05 March 2015) http://healthresearchreport.me/2015/02/26/widely-used-food-additive-promotes-colitis-obesity-and-metabolic-syndrome-research-shows/
Views: 623 VHFILM
The Microbiome in Infectious and Noninfectious Gut Inflammation - Vince Young
 
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July 24-26, 2013 - Human Microbiome Science: Vision for the Future More: http://www.genome.gov/27554404
Special microbes make anti-obesity molecule in the gut
 
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Microbes may just be the next diet craze. Researchers have programmed bacteria to generate a molecule that, through normal metabolism, becomes a hunger-suppressing lipid. Mice that drank water laced with the programmed bacteria ate less, had lower body fat and staved off diabetes — even when fed a high-fat diet — offering a potential weight-loss strategy for humans. Subscribe! http://bit.ly/AmerChemSOc Facebook! https://www.facebook.com/AmericanChem... Twitter! https://twitter.com/ACSpressroom You might also like: Press Conferences from #NOLA: https://www.youtube.com/watch?v=SJoMMnl6eKs&list=PLLG7h7fPoH8Jyqtiv9eOb3nfas3LDxG_p Press Conferences from #Philadelphia: https://www.youtube.com/watch?v=5slYZZAFYQs&list=PLLG7h7fPoH8JNXYo-fCwTiFOqba9VEpv9 Press Conferences from #SanDiego: https://www.youtube.com/watch?v=C9Y17zZoqB0&list=PLLG7h7fPoH8L8o4Um_LZTS2lHxorDgHAH Music: From Audioblocks Produced by the American Chemical Society, the world’s largest scientific society. ACS is a global leader in providing access to chemistry-related information and research through its multiple databases, peer-reviewed journals and scientific conferences. Join the American Chemical Society! https://bit.ly/Join_ACS
Diet and Gut Microbiota - mSystems
 
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Dietary modification has long been used empirically to modify symptoms in inflammatory bowel disease, irritable bowel syndrome, and a diverse group of diseases with gastrointestinal symptoms. There is both anecdotal and scientific evidence to suggest that individuals respond quite differently to similar dietary changes, and the highly individualized nature of the gut microbiota makes it a prime candidate for these differences. To overcome the typical confounding factors of human dietary interventions, here we employ ex-germfree mice colonized by microbiotas of three different humans to test how different microbiotas respond to a defined change in carbohydrate content of diet by measuring changes in microbiota composition and function using marker gene-based next-generation sequencing and metabolomics. Our findings suggest that the same diet has very different effects on each microbiota’s membership and function, which may in turn explain interindividual differences in response to a dietary ingredient. Samuel A. Smits, Angela Marcobal, Steven Higginbottom, Justin L. Sonnenburg, Purna C. Kashyap Pieter C. Dorrestein, Editor Published in mSystems on 6 September 2016 Direct link: http://doi.org/10.1128/msystems.00098-16 mSystems™ publishes preeminent work that stems from applying technologies for high-throughput analyses to achieve insights into the metabolic and regulatory systems at the scale of both the single cell and microbial communities. The scope of mSystems™ encompasses all important biological and biochemical findings drawn from analyses of large data sets, as well as new computational approaches for deriving these insights. mSystems™ welcomes submissions from researchers who focus on the microbiome, genomics, metagenomics, transcriptomics, metabolomics, proteomics, glycomics, bioinformatics, and computational microbiology. mSystems™ provides streamlined decisions, while carrying on ASM's tradition of rigorous peer review. ______________________________________________ Subscribe to ASM's YouTube channel at https://goo.gl/mOVHlK Learn more about the American Society for Microbiology at http://www.asm.org Become a member today at http://www.asmscience.org/join Interact with us on social at: Facebook Show your support and get updates on the latest microbial offerings and news from the ASM. http://www.facebook.com/asmfan ASM International Facebook Groups Join an ASM International Facebook Group and connect with microbiologists in your region. http://www.asm.org/index.php/programs/asm-international-facebook-groups Twitter Follow all the latest news from the Society. http://www.twitter.com/ASMicrobiology Instagram Outstanding images of your favorite viruses, fungi, bacteria and parasites http://www.instagram.com/asmicrobiology/
Household disinfectants could be linked to child obesity
 
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For story suggestions or custom animation requests, contact [email protected] Visit http://archive.nextanimationstudio.com to view News Direct's complete archive of 3D news animations. RESTRICTIONS: Broadcast: NO USE JAPAN, NO USE TAIWAN Digital: NO USE JAPAN, NO USE TAIWAN Commonly used household disinfectants and multi-surface cleaners could be making children overweight by affecting their gut bacteria, according to a study published on Monday in the Canadian Medical Association Journal. Infants living in households where antimicrobial disinfectants were used at least once a week were twice as likely to have elevated levels of the bacteria Lachnospiraceae at ages 3 to 4 months than children whose homes did not use disinfectants frequently, according to CNN. According to Anita Kozyrskyj, lead author of the study, higher levels of Lachnospiraceae in animal studies have been associated with higher body fat and insulin resistance. Researchers collected stool samples from 757 infants and analyzed their body mass index, BMI, at older ages in addition to parental use of disinfectant products. Scientists found that around 80 percent of Canadian households use disinfectant products at least once a week. While the team found an increase in Lachnospiraceae with increased antimicrobial disinfectants, they did not find the same association in disinfectants without the bacteria-killing ingredients or eco-friendly cleaners. "These results suggest that gut microbiota were the culprit in the association between disinfectant use and the overweight," said Kozyrskyj, according to CNN. Though the results show connection between disinfectants and the gut microbiome, that does not imply causation. According to Kozyrskyj, further studies need to be carried out to establish a causal relationship. RUNDOWN SHOWS: 1. Disinfectants affecting an infant's gut bacteria 2. Study parameters 3. Study found elevated levels of Lachnospiraceae in households using more disinfectants 4. Disinfectants without antimicrobial agents were not associated with elevated levels of Lachnospiraceae VOICEOVER (in English): "According to a new study published in the Canadian Medical Association Journal, commonly used household disinfectants and multi-surface cleaners could be making children overweight by affecting their gut bacteria." "According to CNN, researchers collected stool samples from 757 infants, analyzed their body mass index at older ages and parental use of disinfectant products. Higher levels of Lachnospiraceae bacteria in animal studies have been associated with higher body fat." "The study found infants living in households where antimicrobial disinfectants were used at least once a week were twice as likely to have elevated levels of Lachnospiraceae at ages 3 to 4 months old than children whose homes did not use disinfectants frequently." "While the team found an increase in Lachnospiraceae with increased antimicrobial disinfectants, they did not find the same association in disinfectants without the bacteria-killing ingredients or eco-friendly cleaners. This suggests an association between disinfectant use and the overweight." SOURCES: CNN https://edition.cnn.com/2018/09/17/health/disinfectants-baby-gut-microbiota-bmi-study/index.html *** ----------------------------------------­­---------------------------------------­-­---------------- Next Animation Studio’s News Direct service provides daily, high-quality, informative 3D news animations that fill in for missing footage and help viewers understand breaking news stories or in-depth features on science, technology, and health. Sign up for a free trial of News Direct's news animations at http://newsdirect.nextanimationstudio.com/trial/ To subscribe to News Direct or for more info, please visit: http://newsdirect.nextanimationstudio.com
Views: 439 News Direct
Liping Zhao: Diet, Obesity, and Quality FMT Samples
 
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Dr. Liping Zhao, of Shanghai Jiao Tong University, is at the cutting edge of research on how the gut microbiota influence obesity. Gut Microbiota for Health editors are pleased to bring you a video interview with Dr. Zhao as part of our conference highlights from the 2015 Keystone Symposium, "Gut Microbiota Modulation of Host Physiology: The Search for Mechanism". In this video, Dr. Zhao answers the following questions: - How does dietary change affect the microbiota? - Does microbiota modulation have the potential to treat obesity? - In fecal microbiota transplantation, should the donor have a specific diet before giving a sample? - How can you assess the quality of a fecal microbiota transplantation sample? Learn more at: http://www.gutmicrobiotaforhealth.com/en/evidence-for-bacterial-guilds-in-the-gut-ecosystem/
Common Medication Sabotages Metabolism, Causes Obesity
 
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TrutherGirls T-Shirts: http://thetruthergirls.spreadshirt.com Studies show antibiotics alter metabolism and cause weight gain! Some people have the hardest time with their weight and claim they have a slow metabolism. As it turns out, this may actually be true and may have been caused by antibiotics. Fortunately, it looks like there IS a solution which lies in restoring the colonic microbiome, i.e. the healthy bacteria that live in your gut. Antibiotics used to fatten livestock: http://www.huffingtonpost.co.uk/2012/08/22/farmers-obesity-livestock-antibiotics-_n_1821941.html 1955 study shows antibiotics cause increased weight gain in healthy men: http://jn.nutrition.org/content/56/1/151.full.pdf study shows altered gut flora causes weight gain in mice http://www.nature.com/nature/journal/v488/n7413/full/nature11400.html study shows antibiotics exposure in infancy is linked to higher body mass index later: http://www.nature.com/ijo/journal/vaop/ncurrent/abs/ijo2012132a.html altering gut microbiome directly also alters carbohydrate metabolism and body mass in mice http://www.ncbi.nlm.nih.gov/pubmed/17183312 fecal transplant in obese men alters carbohydrate metabolism, lowers weight http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2705 more info: http://www.nytimes.com/2012/06/19/science/studies-of-human-microbiome-yield-new-insights.html?pagewanted=all gut microbiome: http://www.nature.com/nature/journal/v485/n7398_supp/full/485S12a.html
Views: 4847 thetruthergirls
Fat Mice Linked to Gut Microbes
 
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Science News reports new research in rodents suggests gut microbes cause obesity by sending messages via the vagus nerve to pack on pounds. In the June 9th issue of Nature magazine, researchers report bacteria in the intestines produce a molecule called acetate, which works through the brain and nervous system to make rats and mice fat. Yale University endocrinologist Gerald Shulman led the study. He said acetate also increases levels of a hunger hormone called ghrelin, which could lead animals and people to eat even more. Biochemist Jonathan Schertzer of McMaster University in Hamilton, Canada, called the paper a “tour-de-force." https://www.sciencenews.org/article/obesity%E2%80%99s-weight-gain-message-starts-gut http://www.wochit.com This video was produced by YT Wochit News using http://wochit.com
Views: 545 Wochit News
How The Gut Microbiota Affects Our Health with Dr. Erica & Dr. Justin Sonnenburg
 
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Dr. Justin Sonnenburg is an associate professor of microbiology and immunology at Stanford and Dr. Erica Sonnenburg is a senior research scientist in the Sonnenburg lab where they the research many aspects the interaction between diet with the 100 trillion or so bacteria in the gut (specifically the colon) and how this impacts the health of the host (which in this case is a laboratory research mouse). In this episode we discuss the pivotal role fiber plays in fueling good bacteria in the gut to produce compounds that regulate the immune system including increasing the number of T regulatory cells, which are specialized types of immune cells that keep the immune system in check and prevent autoimmune responses, and how these compounds also increase other types of blood cells in the body in a process known as hematopoiesis. We also talk about how the lack of fiber in the typical American diet actually starves these good bacteria of their food. This has an effect not only on the immune system and autoimmune diseases but also results in the breakdown of the gut barrier, which leads to widespread inflammation and inflammatory diseases. Lastly, in this podcast, Dr. Erica Sonnenburg talks about how C-sections, have a negative effect on the infant’s gut due to the lack of exposure to bacteria present in the mother’s vaginal canal, and how the use of formula deprives the infant not only from the good bacteria present in Mom’s gut but also from special carbohydrates in breast milk that are good for the infant gut flora known as HMOs or human milk oligosaccharides. ▶︎ Get the show notes! https://www.foundmyfitness.com/episodes/the-sonnenburgs Links related to the Sonnenburgs: ▶︎ http://sonnenburglab.stanford.edu/ ▶︎ http://www.facebook.com/thegoodgut ▶︎http://www.amazon.com/gp/product/1594206287/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=1594206287&linkCode=as2&tag=foun06-20&linkId=IOKAGDTRCL47XQN6 Links related to FoundMyFitness: ▶︎ Join my weekly newsletter: http://www.foundmyfitness.com/?sendme=nutrigenomics ▶︎ Crowdfund more videos: http://www.patreon.com/foundmyfitness ▶︎ Subscribe on YouTube: http://www.youtube.com/subscription_center?add_user=foundmyfitness ▶︎ Subscribe to the podcast: http://itunes.apple.com/us/podcast/foundmyfitness/id818198322 ▶︎ Twitter: http://twitter.com/foundmyfitness ▶︎ Facebook: http://www.facebook.com/foundmyfitness ▶︎ Instagram: http://www.instagram.com/foundmyfitness
Views: 131125 FoundMyFitness
HOW STRESS IS RELATED TO GUT MICROBIOTA
 
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REFERENCES Bailey, MT, Dowd, SE, Parry, NMA, Galley, JD, Schauer, DB & Lyte, M 2010, ‘Stressor exposure disrupts commensal microbial populations in the intestines and leads to increased colonization by Citrobacter rodentium’, Infection and Immunity, vol. 78, no. 4, pp. 1509-1519. Bercik, P, Denou, E, Collins, J, Jackson, W, Lu, J, Jury, J, Deng, Y, Blennerhassett, P, Macri, J, McCoy, KD, Verdu, EF & Collins, SM 2011, ‘The intestinal microbiota affect central levels of brain-derived neurotropic factor and behaviour in mice’, Gastroenterology, vol.141, no. 2, pp. 599-609. Carabotti, M, Scirocco, A, Maselli, MA, Severi, C 2015, ‘The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems’, Annals of Gastroenterology : Quarterly Publication of the Hellenic Society of Gastroenterology, vol. 28, no.2, pp.203-209. Foster, JA & Neufeld, KM 2013, ‘Gut-brain axis: how the microbiome influences anxiety and depression’, Trends in Neurosciences, vol. 36, no. 5, pp. 305-312. Foster, J, Rinaman, L and Cryan, J, 2017, ‘Stress & the gut-brain axis: Regulation by the microbiome’, Neurobiology of Stress, pp.1-13. Gunawardene AR, Corfe BM, Staton CA 2011, ‘Classification and functions of enteroendocrine cells of the lower gastrointestinal tract’, International Journal of Experimental Pathology, vol.92, no.4, pp.219-231. Integrative HMP Research Network Consortium 2014, ‘The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health and disease’, Cell Host Microbe, vol. 3. J Clin Invest. 2007;117(1):13-23. doi:10.1172/JCI30227 Moloney, RD, Desbonnet, L, Clarke, G, Dinan, TG & Cryan, JF 2014, ‘The microbiome: stress, health and disease’, Mammalian Genome, vol. 25, no. 1-2, pp. 49-74. O’Mahony, SM, Marhesi, JR, Scully, P, Codling, CC, Ceolho, AM, Quigley, EMM, Cryan, JF & Dinan, TG 2009, ‘Early life stress alters behaviour, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses’, Biological Psychiatry, vol. 65, no. 3, pp. 263-276. Peterson, J, Garges, S, Giovanni, M, McInnes, P, Wang, L, Schloss, J, Bonazzi, V, McEwa, J, Howcroft, T, Karp, R, Lunsford, R, Wellington, C, Belechew, T, Wright, M Giblin, C, David, H, Mills, M, Salomon, R, Mullins, C, Akolkar, B, Begg, L, Davis, C, Grandison, L, Humble, M, Khalsa, J, Little, A, Peavy, H, Pontzer, C, Portney, M, Sayre, M, Starke-Reed, P, Zakhari, S, Read, J, Watson & B, Guyer, M 2009, ‘The NIH Human Microbiome project’, Genome Research, vol. 12, 2317–2323. Rea, K, Dinan, TG & Cryan, JF 2016, ‘The microbiome:a key regulator of stress and neuroinflammation’, Neurobiology of Stress, vol. 4, 23-33. Sudo, N, Chida, Y, Aiba, Y, Sonoda, J, Oyama, N, Yu, X, Kubo, C & Koga, Y 2004, ‘Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice’, The Journal of Physiology, vol. 558, no. 1, pp. 263-275. Edit: reference for image of endocrine cell, J Clin Invest. 2007;117(1):13-23. doi:10.1172/JCI30227
Views: 669 Jacqui Scaffidi
Latest Science Discovery (No. 7): Protein Causes Over 33% Fat Reduction in Obese Mice
 
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A research team lead by Georgetown University biomedical researchers has made a startling discovery using mouse models. To learn more, check out this video and share it with your network today. Researchers: Elena Tassi, Khalid A. Garman, Marcel O. Schmidt, Xiaoting Ma, Khaled W. Kabbara, Aykut Uren, York Tomita, Regina Goetz, Moosa Mohammadi, Christopher S. Wilcox, Anna T. Riegel, Mattias Carlstrom, and Anton Wellstein The forced expression of a protein in a laboratory strain of obese mice showed a remarkable reduction of their fat mass The protein FGFBP3 (BP3) modulates fat and glucose metabolism in mouse models of metabolic syndrome In obese mice, the expression of exogenous BP3 reduced hyperglycemia, hepatosteatosis, and weight gain The research team concluded that BP3 could be used to reverse the pathology associated with metabolic syndrome According to Dr. Anton Wellstein, eight BP3 treatments over 18 days caused over 33% fat reduction in obese mice The BP3 protein treatment also reduced blood sugar in obese mice to a significant extent Further studies would be required to assess the BP3 effect on human subjects Publication link: https://www.nature.com/articles/s41598-018-34238-5 Need a professionally created video for promoting your service, product, or event? Let https://videonium.com help you. Please make sure you LIKE, SHARE, COMMENT, AND SUBSCRIBE. Do share this resourceful video with your friends on Facebook, Twitter, and YouTube. Place your first order on https://videonium.com today!
Views: 826 Videonium's Channel
Pesticide Causes Obesity And Obesity Causes Diabetes
 
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New examination discovers how pesticide presentation causes obesity Another investigation has discovered that the utilization of pesticides expands the danger of creating obesity by disabling gut and gut microbiota. Chlorpyrifos has been a private bug spray since the late nineteenth century, and it is still among the most generally utilized sort of pesticide around the globe because of its optimal bioactivity. Past examinations demonstrate that introduction to the pesticide may cause obesity and diabetes, however the basic system of how it functions stays obscure. Specialists from China Agriculture University concentrated on the human gut microbiota, the most essential small scale biological community in the body. Gut microbiota, containing many trillions of microorganisms, has essential impacts incorporating into insusceptibility and body weight. It can enable the body to process certain sustenances that the stomach and small digestive tract have not had the capacity to process. In creature tests, analysts put the pesticide into the sustenance and water of mice. They found the pesticide admission broke the uprightness of the gut hindrance, prompting an expanded section of a poison into the body lastly aggravation, which eventually instigated insulin opposition and obesity. Insulin obstruction is generally observed in fat individuals and assumes a key job in the advancement of diabetes. As indicated by Wang Peng, lead scientist, the expanded poison bearing microorganisms populace in the body further upsets the gut microbiota balance, making the mice acquire fat. In addition, comparable outcomes were seen in mice with various hereditary foundations and diet propensities, showing that qualities and diet had restricted effect on the modified gut and gut microbiota. The exploration was distributed in the universal diary Microbiome. "Our outcomes propose that across the board utilization of pesticides may add to the overall pandemic of aggravation related ailments," Wang said. ---------------------------------------------------------------------------- Useful Links: 1. Connect on facebook by liking our page: https://www.facebook.com/Thinkingisajob/ 2. Get updates Instagram: https://www.instagram.com/Thinkingisajob/ 3. Visit our Website: https://thinkingisajob.com 4. Indian Shop Global Products: https://thinkingisajob.com/product/ -------------------------------------------------------------------- #PESTICIDE #OBESITY #DIABETES You found this video because you searched for one of the following: pesticide pollution in india pesticides pesticides meaning in hindi pesticide examples pesticide meaning in hindi pesticide of india obesity causes of obesity obesity causes obesity in india causes of obesity and type 2 diabetes causes of obesity and diabetes
Views: 99 Nandan Verma