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Microbiome: Gut Bugs and You | Warren Peters | TEDxLaSierraUniversity
 
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Can gut bugs change the world? Join Warren Peters on a journey into understanding your microbiome and the new discoveries changing the way we understand diabetes, obesity, Alzheimer's disease, autism, and our everyday health and wellness. If asked, he will tell you that the first part of his medical career was in general surgery, where “if something is wrong with you, I will cut it out." The next was dedicated to lifestyle and natural medicines, where “if something is wrong with you, just try harder." And finally, the last part is dedicated to the molecular and genetic basis of obesity, where "if something is wrong with you, it is the fault of your parents and the changing environment." Within these three perspectives, reside the virtues of common sense and wisdom. He obtained his medical degree from Loma Linda University, his surgical training at the Mason Clinic in Seattle Washington, and, his Master’s degree in biostatistics and epidemiology from Loma Linda University. He is privileged to travel and lecture nationally and internationally on topics of nutrition, wholeness, and wellness. He has practiced surgical care, wholistic care, and, primary care in Washington, Maryland, Virginia, and California. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx
Views: 118713 TEDx Talks
Microbiome and Obesity - Martin Blaser
 
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July 24-26, 2013 - Human Microbiome Science: Vision for the Future More: http://www.genome.gov/27554404
Human Science (Part 1) - The Gut Brain Axis, Microbiome & the power of Probiotics
 
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Fascinating new research tells us that our gut exerts an influence on the brain, affecting our mood, hormonal balance and obesity levels. Ps. Big welcome to all new subscribers! For more research, here's a starting point: https://www.psychologytoday.com/blog/inner-source/201411/the-gut-microbiome-anxiety-and-depression-6-steps-take Also: http://www.drperlmutter.com/research-probiotic-intervention-affects-mood/ Sneaky Snitch Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 3.0 License http://creativecommons.org/licenses/by/3.0/ You can support this channel here: https://www.patreon.com/infognostica
Views: 30894 Infognostica
Antibiotic Exposure, The Microbiome and Obesity
 
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A number of variables can cause signficant changes in the human microbiome early in life including birth method and antibiotic exposure. Understanding these shifts is important because new research suggests that shifts in the microbiome of infants could make them more prone to gain weight as adults. Participants will discuss variables involved in the development of the infant microbiome and how it affects adult metabolism and body composition in mouse models. Laura Cox, NYU Langone Medical Center Elizabeth Costello, Stanford University School of Medicine
Bacteria in gut may cause morbid obesity
 
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Susan Hendricks reports on new data that find bacteria in the gut may cause obesity. For more CNN videos, check out our YouTube channel at http://www.youtube.com/cnn Or visit our site at http://www.cnn.com/video/
Views: 2115 CNN
The GUT BIOME: artificial sweeteners;Yo-Yo diets; regaining weight?
 
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Prevmedheartrisk.com In 2015, researchers at the Weisman Institute in Israel demonstrated that saccharin, sucralose and aspartame created insulin resistance in lab mice. Antibiotic treatment and repopulation with normal bacteria cured the glucose intolerance. Other studies have shown that faecal transplants from obese humans made lab mice gain weight. In fact, gut biome or bacteria have been demonstrated to cause "yoyo" dieting effects, going back to pre-diet weights. One researcher decided to make mouse chow pellets out of breakfast cereal and pizza. Obese rats given this pizza/cereal chow did not lose weight after faecal transplant. Obese rats given regular diet did lose weight after faecal transplant. About Dr. Brewer - Ford Brewer is a physician that started as an Emergency Doctor. After seeing too many patients coming in dead from early heart attacks, he went to Johns Hopkins to learn Preventive Medicine. He went on the run the post-graduate training program (residency) in Preventive Medicine at Hopkins. From there, he made a career of practicing and managing preventive medicine and primary care clinics. His later role in this area was Chief Medical Officer for Premise, which has over 500 primary care/ prevention clinics. He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack, stroke, and diabetes prevention clinic. At PrevMed, we focus on heart attack and stroke and Type 2 diabetes prevention by reducing or eliminating risk through attentive care and state-of-the-art genetic testing, imaging, labs and telemedicine options. We serve patients who have already experienced an event as well as those have not developed a diagnosis or event. Our team of senior clinicians includes internationally recognized leaders in the research and treatment of cardiovascular disease, preventive medicine and wellness. We also provide preventive medicine by telemedicine technology to over 30 states. Contact Dr. Brewer at [email protected] or visit http://prevmedheartrisk.com. -~-~~-~~~-~~-~- Please watch: "How to prevent a stroke: #1 cause of disability, #5 cause of death, High BP and Atrial fibrillation" https://www.youtube.com/watch?v=buRtcJyLFJA -~-~~-~~~-~~-~-
Views: 807 Ford Brewer
Human gut microbes slim mice
 
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The mix of microbes living inside the gut can protect against obesity, but a healthy diet is critical, according to Washington University School of Medicine scientists who transplanted intestinal microbes from obese and lean twins into mice and fed the animals different diets. Animation by Vanessa Ridaura and Victor Ridaura. https://source.wustl.edu/2013/09/altering-mix-of-gut-microbes-prevents-obesity-but-diet-remains-key-factor/
Utilizing Gnotobiotic Mice to Understand the Role of the Microbiome in Murine Disease Models
 
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The environmentally exposed surfaces of mammals, such as the skin, mouth, gut, and vagina, are colonized by a diverse ecosystem of microbes. Though many of these bacteria - particularly those of the distal gut - are considered symbiotic, the microbiome has the capacity to induce both pro- and anti- inflammatory responses. Accumulating evidence suggests that a properly balanced gut microbiome is crucial for a correctly functioning immune system, and that imbalances in the microbial community of the intestine are linked to a multitude of auto-inflammatory and auto-immune diseases. This symposium will discuss the roles of the microbiome in murine models of various inflammatory disease states, and the advantages to utilizing germ-free/gnotobiotic mice when probing disease models with a microbiome component.
Views: 282 Biomodels, LLC
Obesity and the Microbiota
 
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3 Roundtable Symposia from ASPEN Clinical Nutrition Week 2015: Microbiome
MICROBIOTA, ANTIBIOTICS AND OBESITY
 
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MICROBIOTA, ANTIBIOTICS AND OBESITY
Views: 92 Massimo Zappia
Special microbes make anti-obesity molecule in the gut
 
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Microbes may just be the next diet craze. Researchers have programmed bacteria to generate a molecule that, through normal metabolism, becomes a hunger-suppressing lipid. Mice that drank water laced with the programmed bacteria ate less, had lower body fat and staved off diabetes — even when fed a high-fat diet — offering a potential weight-loss strategy for humans. Subscribe! http://bit.ly/AmerChemSOc Facebook! https://www.facebook.com/AmericanChem... Twitter! https://twitter.com/ACSpressroom You might also like: Press Conferences from #NOLA: https://www.youtube.com/watch?v=SJoMMnl6eKs&list=PLLG7h7fPoH8Jyqtiv9eOb3nfas3LDxG_p Press Conferences from #Philadelphia: https://www.youtube.com/watch?v=5slYZZAFYQs&list=PLLG7h7fPoH8JNXYo-fCwTiFOqba9VEpv9 Press Conferences from #SanDiego: https://www.youtube.com/watch?v=C9Y17zZoqB0&list=PLLG7h7fPoH8L8o4Um_LZTS2lHxorDgHAH Music: From Audioblocks Produced by the American Chemical Society, the world’s largest scientific society. ACS is a global leader in providing access to chemistry-related information and research through its multiple databases, peer-reviewed journals and scientific conferences. Join the American Chemical Society! https://bit.ly/Join_ACS
Obesity and Microbiome
 
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Mygerm helps you to choose the right Probiotics! You will get more information about microbiome and probiotics. Please come and check out our recommendations of probiotic products. www.mygerm.com
Views: 615 MyGerm
Pediatric Gut Microbiota, Antibiotics, and Obesity
 
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References: 1. Dietitians of Canada. Gastrointestinal System – Microbiota. In: Practice-based Evidence in Nutrition [PEN]. 2016 July 27 [cited 2016 Dec 1]. Available from: http://www.pennutrition.com.ezproxy.library.ubc.ca/KnowledgePathway.aspx?kpid=24357&trid=25391&trcatid=38. Access only by subscription. 2. Canadian Society of Intestinal Research. Gut Bacteria: Manipulating body fat, mood, and IBS by mixing up the microorganisms in your gut. Inside Tract. 2014;(190), 20-21. 3.Ridaura V, Faith J, Rey F, Cheng U, Duncan A, Gordon J, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 2013 Sep 6, [cited November 3, 2016]; 341(6150): 1241214. Available from: http://science.sciencemag.org.ezproxy.library.ubc.ca/content/341/6150/1241214.full 4. Koleva P, Bridgman S, Kozyrskyj, A. The infant gut microbiome: evidence for obesity risk and dietary intervention. Nutrients. 2015 March 31 [cited December 1, 2016]; 7(4): 2237-2260. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425142/  5. Trasande L, Blustein J, Liu M, Corwin E, Cox LM, Blaser MJ. Infant antibiotic exposures and early-life body mass. International journal of obesity. 2013 Jan 1 [cited November 3, 2016];37(1):16-23. 6. Korpela K, Salonen A, Virta LJ, Kekkonen RA, Forslund K, Bork P, de Vos WM. Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children. Nature Communications. 26 Jan 2016. [cited December 1, 2016];10410. Available from: http://www.nature.com/articles/ncomms10410 7. Schwartz BS, Pollak J, Bailey-Davis L, Hirsch AG, Cosgrove SE, Nau C, Kress AM, Glass TA, Bandeen-Roche K. Antibiotic use and childhood body mass index trajectory. International Journal of Obesity. 2016 Apr 1 [cited November 3, 2016];40(4):615-21.
Views: 448 Claudia Wong
Lora Hooper (UT Southwestern) 1: Mammalian gut microbiota: Mammals and their symbiotic gut microbes
 
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https://www.ibiology.org/immunology/gut-microbiota/ Overview: Dr. Hooper studies how the gut microbiota changes during illness or disease and how it influences our ability to fight infections. In part 2, Hooper explains how a healthy gut microbes induce a host protein called RegIIIγ which helps to protect the host from infection by pathogenic gram-positive bacteria. Detailed description: In this lecture, Dr. Hooper introduces us to the fascinating world of human microbiota; the microorganisms that live within our bodies. Although we may think that most bacteria are harmful, Hooper provides ample evidence that symbiotic gut microbes are important to good human health. Her lab is interested in understanding how the microbiota changes during illness or disease and how it influences our ability to fight infections. Using germ-free mice, they were able to demonstrate that a healthy microbiota can shape development of the host immune system and provide protection against dangerous infections like salmonella. In the second part of her talk, Hooper explains how the balance of organisms in the microbiota is maintained. By comparing DNA microarray data from normal mice and germ-free mice, Hooper’s lab was able to look for genes induced by the microbiota. They identified RegIIIγ, an important protein involved in the protection against pathogenic bacteria. They showed that RegIIIγ forms pore complexes in the membranes of gram-positive bacteria and kills them. In mice and humans, the intestinal epithelium is coated with a layer of mucus. Typically, there is a gap between gut bacteria, which are found in the outer part of the mucus layer, and the epithelial cells. Hooper’s lab showed that RegIIIγ helps to maintain this gap by preventing gram-positive bacteria from colonizing the intestinal epithelial surface. This, in turn, prevents infection of the host. Speaker Biography: Although she always was interested in science, Lora Hooper’s love for biology started after taking an introductory class at Rhodes College in Memphis, TN where she was an undergraduate. Hooper continued her graduate education in the Molecular Cell Biology and Biochemistry Program at Washington University in St. Louis where she joined Dr. Jacques Baenziger's lab. For postdoctoral training, she stayed at Washington University, in the lab of Jeffrey Gordon, where she began her studies of the interaction between gut bacteria and host cells and discovered that bacteria have the capacity to modify carbohydrates important for cell signaling. Currently, Hooper is a Professor at The University of Texas Southwestern Medical Center and a Howard Hughes Medical Institute Investigator. She has established one of the handful of mouse facilities that have the capacity to breed germ-free mice. Using these mice, her lab explores the symbiotic relationship between a host and its microbiota with the aim of providing insight into human health. Hooper was a recipient of the Edith and Peter O’Donnell Awards in 2013 and in 2015 she was elected to the National Academy of Sciences.
Views: 5688 iBiology
Obesity, The Microbiome And "Alexander Microbes" [Functional Forum, James Maskell]
 
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http://goevomed.com/ Dr. Leo Galland discusses the human microbiome, and the importance of “Alexander Microbes” in combatting obesity in this video segment from the May 2015 Functional Forum. http://goevomed.com/hc Check out our August Functional Forum episode; a collaboration with the Institute for Functional Medicine. ---------------------------------------------------------------------------------- Filmed on location at the IFM’s Annual International Conference in May 2015, this Forum focused on not only the emerging “Omics” Revolution, but also the implications of that new understanding for patient care. From emerging mainstream TV stars to an update from Mark Hyman, MD about the Cleveland Clinic, this episode features some of the big names and rising stars in Functional Medicine, especially those innovating business models and showing very clearly the “Future of Functional”. This 90 minute show also features an extended session with George Slavich, PhD, whose talk was one the highlights of the conference looking at an emerging field: Social Genomics. https://www.functionalmedicine.org/conference.aspx?id=2972&cid=116&section=purchase http://youtu.be/q9vkR9xdoRU GoEvoMed
Views: 3005 Functional Forum
Gut Microbiota & Obesity: The right equilibrium to loose weight. With Eran Elinav
 
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Eran Elinav (Weizmann Institute) tries to understand how gut microbiota can affect health and favor the development of diseases like diabetes. In this video, he presents his incredible results on Obesity and the development of a personalized nutrition to sustainably loose weight.
Why Is Healthy Gut Flora So Important for Weight Loss?
 
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Gut bacteria have an immense impact on our weight and body composition. But, despite their importance, we keep starving them out by eating highly processed food, and killing them with overuse of antibiotics. Visit Bites of Reason on: Facebook: https://www.facebook.com/bitesofreason Twitter: https://twitter.com/BitesOfReason ____________________ Created by Krunoslav Vinicki Research / Writing / Editing/Animation Lea Kralj Jager (http://smallfox.net/) Art Danko Bundalo (Soundcloud: https://soundcloud.com/dbundalo) Narration / Script / Sound ____________________ References: 1. Gill H.S., Guarner, F. (2004). Probiotics and human health: a clinical perspective. Postgraduate Medical Journal, 80:516-526. http://pmj.bmj.com/content/80/947/516 2. Fujimura, K. E. et al., “Role of the gut microbiota in defining human health,” Expert Review of Anti-infective Therapy 8, no. 4 (April 2010): 435–54, http://pmid.us/20377338. 3. Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Gordon, J. I. (2009). A core gut microbiome in obese and lean twins. Nature, 457(7228), 480–484. http://www.ncbi.nlm.nih.gov/pubmed/19043404 4. Blustein, J., Attina, T., Liu, M., Ryan, M., Cox, L. M., Blaser, M. J., Trasande, L. (2013). Association of caesarean delivery with child adiposity from age 6 weeks to 15 years. International Journal of Obesity, 37, 900–906. http://www.nature.com/ijo/journal/v37/n7/abs/ijo201349a.html 5. Hyde, M.J., Modi, N. (2012). The long-term effects of birth by caesarean section: the case for a randomised controlled trial. Early Human Development, 88(12), 943-9. http://www.ncbi.nlm.nih.gov/pubmed/23036493 6. Trasande, L., Blustein, J., Liu, M., Corwin, E., Cox, L., & Blaser, M. (2013). Infant antibiotic exposures and early-life body mass. International Journal of Obesity, 37(1), 16–23. http://www.ncbi.nlm.nih.gov/pubmed/22907693 7. Vanessa K. Ridaura, V. K. et al. (2013), Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science, 341 (6150). http://science.sciencemag.org/content/341/6150/1241214.article-info 8. OECD, Obesity and the Economics of Prevention: Fit not Fat - Korea Key Facts http://www.oecd.org/els/health-systems/obesityandtheeconomicsofpreventionfitnotfat-koreakeyfacts.htm 9. Kim, E. K., An, S.Y., Lee, M. S., Kim, T. H., Lee, H. K., Hwang, W. S., Choe, S. J., Kim, T. Y., Han, S. J., Kim, H. J., Kim, D. J., Lee, K.W. (2011). Fermented kimchi reduces body weight and improves metabolic parameters in overweight and obese patients. Nutrition Research, 31(6), 436-43. http://www.ncbi.nlm.nih.gov/pubmed/21745625
Views: 3251 Bites of Reason
Demystifying Medicine 2017: Obesity: Brown and Other Fat
 
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Demystifying Medicine 2017: Obesity: Brown and Other Fat Air date: Tuesday, March 28, 2017, 4:00:00 PM Category: Demystifying Medicine Runtime: 01:30:01 Description: The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. Each lecture will feature a presentation on a major disease, including current research and advancements on treatments. For more information go to https://demystifyingmedicine.od.nih.gov Author: Aaron Cypess, MD, PhD, MMSc, NIDDK, NIH and Rebecca Brown, MD, MHSc, NIDDK, NIH Permanent link: https://videocast.nih.gov/launch.asp?22202
Views: 1698 nihvcast
Obesity and Type 2 Diabetes Alters the Immune Properties of Human Adipose Derived Stem Cells
 
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Video abstract from Drs. Serena, Keiran, Ceperuelo-Mallafre, Ejarque, Fradera, Roche, Nuñez-Roa, Vendrell, and Férnandez-Veledo on their recently published STEM CELLS paper entitled, "Obesity and Type 2 Diabetes Alters the Immune Properties of Human Adipose Derived Stem Cells" Read the Paper Here: http://onlinelibrary.wiley.com/doi/10.1002/stem.2429/abstract
Views: 359 WileyVideoAbstracts
Bacteria From Obese People Make Mice Fatter
 
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According to data from a recent study by researchers at Washington University in St. Louis, Missouri, germs transplanted from obese people made mice gain weight. According to data from a recent study by researchers at Washington University in St. Louis, Missouri, germs transplanted from obese people made mice gain weight. For the study, researchers took fecal samples from pairs of twins that had one skinny twin and one obese twin, to see how they would affect the mice who are identical and were raised to have no bacteria produced in their stomachs. When researchers fed the fecal samples from the digestive tract of the obese twin to the lab mice, it made them fatter. The researchers also fed fecal samples from the stomachs of the skinny twin to mice and found that the bacteria in it actually prevented them from gaining weight. It is common for mice to eat each other's feces and exchange bacterial microbes but the germs from the skinny twin out-competed the germs from the obese twin. Jeffrey Gordon, the senior investigator of the study said: "Eating a healthy diet encourages microbes associated with leanness to quickly become incorporated into the gut. But a diet high in saturated fat and low in fruits and vegetables thwarts the invasion of microbes associated with leanness." The results of the study might be used to come up with a probiotic bacteria that can be taken to manage weight loss.
Views: 1750 GeoBeats News
Fecal transplants & why you should give a crap | Mark Davis | TEDxSalem
 
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How swallowing someone else's poop could save your life! Dr. Mark Davis is a Portland-based naturopath who specializes in stomach and intestinal health. He is an expert in fecal transplantation, having successfully administered it for patients of many conditions. Davis cofounded Microbiomes, LLC, which was the first group in the U.S. to offer a fecal transplant capsule, which is taken orally. He hopes that the U.S. Food and Drug Administration will eventually allow more patients to benefit from fecal transplantation. Live interpretation by Ben Cavaletto, post interpretation by Mish Ktejik. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx
Views: 39644 TEDx Talks
Treating the Microbiota in Obesity
 
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A study was just published in which a group of women received a microbiota treatment, with prebiotics, while having their microbiota’s and weight tracked. Did the microbiota shift? Did this cause weight loss? Let’s review the findings. Want more info? Email us at [email protected], call at (800) 335-7009 and visit me at http://www.DrRuscio.com. For your free e-book on gut health, click here: http://drruscio.com/youtube-subscription/ Dr. Ruscio is your leading functional and integrative doctor specializing in gut related disorders such as SIBO, leaky gut, Celiac, IBS and in thyroid disorders such as hypothyroid and hyperthyroid. For more information on how to become a patient, please contact our office. Serving the San Francisco bay area and distance patients via phone and Skype.
What is the microbiome?
 
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Our human cells are outnumbered by microbial cells - so are we more microbe than human? Subscribe to Nourishable at https://www.youtube.com/c/Nourishable Follow Nourishable on twitter, facebook and instagram to stay up to date on all things nutrition. https://twitter.com/nourishable fb.me/nourishable.tv https://www.instagram.com/nourishable/ Hosting, Research, Writing & Post-Production by Lara Hyde, PhD http://www.nourishable.tv Music & Video Production by Robbie Hyde https://www.youtube.com/user/chedderchowder Motion Graphics by Jay Purugganan https://www.c9studio.com/WP/ Script with in-text citations https://goo.gl/C3qRMW Images: personal collection, shutterstock, pixabay, www.vecteezy.com/ by veernavya, lavarmsg, ayaankabir, seabranddesign, momentbloom The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this video is for general information purposes only. References Bianconi et al. 2013. “An Estimation of the Number of Cells in the Human Body.” Annals of Human Biology 40 (6): 463–71. Butel, M-J. 2014. “Probiotics, Gut Microbiota and Health.” Médecine et Maladies Infectieuses 44 (1): 1–8. Chen et al. 2017. “The Microbiota Continuum along the Female Reproductive Tract and Its Relation to Uterine-Related Diseases.” Nature Communications 8 (1): 875. David et al. 2014. “Diet Rapidly and Reproducibly Alters the Human Gut Microbiome.” Nature 505 (7484): 559–63. Dinan et al. 2017. “The Microbiome-Gut-Brain Axis in Health and Disease.” Gastroenterology Clinics of North America 46 (1): 77–89. “Federal Engagement in Antimicrobial Resistance | Antibiotic/Antimicrobial Resistance | CDC.” https://www.cdc.gov/drugresistance/federal-engagement-in-ar/index.html#tabs-835289-5. Flint et al. 2015. “Links between Diet, Gut Microbiota Composition and Gut Metabolism.” The Proceedings of the Nutrition Society 74 (1): 13–22. Hansen et al. 2014. “Impact of the Gut Microbiota on Rodent Models of Human Disease.” World Journal of Gastroenterology: WJG 20 (47): 17727–36. “Human Microbiome Project - Public Health Relevance | NIH Common Fund.” n.d. Accessed May 22, 2018. https://commonfund.nih.gov/hmp/public. Jeffery et al. 2013. “Diet-Microbiota Interactions and Their Implications for Healthy Living.” Nutrients 5 (1): 234–52. Jenkins et al. 2016. “Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis.” Nutrients 8 (1). https://doi.org/10.3390/nu8010056. LeBlanc et al. 2013. “Bacteria as Vitamin Suppliers to Their Host: A Gut Microbiota Perspective.” Current Opinion in Biotechnology 24 (2): 160–68. Lloyd-Price et al. 2017. “Strains, Functions and Dynamics in the Expanded Human Microbiome Project.” Nature 550 (7674): 61–66. Montoya-Williams et al. 2018. “The Neonatal Microbiome and Its Partial Role in Mediating the Association between Birth by Cesarean Section and Adverse Pediatric Outcomes.” Neonatology 114 (2): 103–11. O’Mahony et al. 2015. “Serotonin, Tryptophan Metabolism and the Brain-Gut-Microbiome Axis.” Behavioural Brain Research 277 (January): 32–48. Pascale et al. 2018. “Microbiota and Metabolic Diseases.” Endocrine. https://doi.org/10.1007/s12020-018-1605-5. Perez-Muñoz et al. 2017. “A Critical Assessment of the ‘sterile Womb’ and ‘in Utero Colonization’ Hypotheses: Implications for Research on the Pioneer Infant Microbiome.” Microbiome 5 (1). https://doi.org/10.1186/s40168-017-0268-4. Pimentel et al. 2013. “Gas and the Microbiome.” Current Gastroenterology Reports 15 (12). https://doi.org/10.1007/s11894-013-0356-y. Ridaura et al. 2013. “Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice.” Science 341 (6150): 1241214. Sender et al. 2016. “Revised Estimates for the Number of Human and Bacteria Cells in the Body.” PLoS Biology 14 (8): e1002533. Tamburini et al. 2016. “The Microbiome in Early Life: Implications for Health Outcomes.” Nature Medicine 22 (7): 713–22. Theriot & Young. 2015. “Interactions Between the Gastrointestinal Microbiome and Clostridium Difficile.” Annual Review of Microbiology 69 (1): 445–61. Turnbaugh et al. 2009. “A Core Gut Microbiome in Obese and Lean Twins.” Nature 457 (7228): 480–84. Turnbaugh et al. 2006. “An Obesity-Associated Gut Microbiome with Increased Capacity for Energy Harvest.” Nature 444 (7122): 1027–31. Versini et al. 2015. “Unraveling the Hygiene Hypothesis of Helminthes and Autoimmunity: Origins, Pathophysiology, and Clinical Applications.” BMC Medicine 13 (April): 81. Vrieze et al. 2012. “Transfer of Intestinal Microbiota from Lean Donors Increases Insulin Sensitivity in Individuals with Metabolic Syndrome.” Gastroenterology 143 (4): 913–16.e7. Yano et al. 2015. “Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis.” Cell 161 (2): 264–76.
Views: 202 Nourishable
Widely used food additive promotes colitis, obesity and metabolic syndrome
 
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* Please pass on to those with digestion concerns - Widely used food additive promotes colitis, obesity and metabolic syndrome, research shows The team fed mice two very commonly used emulsifiers, polysorbate 80 and carboxymethylcellulose, at doses seeking to model the broad consumption of the numerous emulsifiers that are incorporated into almost all processed foods. Such changes in bacteria triggered chronic colitis in mice genetically prone to this disorder, due to abnormal immune systems. In contrast, in mice with normal immune systems, emulsifiers induced low-grade or mild intestinal inflammation and metabolic syndrome, characterized by increased levels of food consumption, obesity, hyperglycemia and insulin resistance. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome Nature 519, 92–96 (05 March 2015) http://healthresearchreport.me/2015/02/26/widely-used-food-additive-promotes-colitis-obesity-and-metabolic-syndrome-research-shows/
Views: 592 VHFILM
Gut microbiota and obesity, what comes first?
 
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Dr. Thomas Greiner explains that the gut microbiota is influenced by your genes, who you're born from and you diet. However the gut microbiota is different between obese and lean patients. In the future studies may discover a right mixture of the bacteria and prevent obesity.
Microbiome and Obesity
 
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Microbiome
Views: 188 EmergingScience
Common Medication Sabotages Metabolism, Causes Obesity
 
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TrutherGirls T-Shirts: http://thetruthergirls.spreadshirt.com Studies show antibiotics alter metabolism and cause weight gain! Some people have the hardest time with their weight and claim they have a slow metabolism. As it turns out, this may actually be true and may have been caused by antibiotics. Fortunately, it looks like there IS a solution which lies in restoring the colonic microbiome, i.e. the healthy bacteria that live in your gut. Antibiotics used to fatten livestock: http://www.huffingtonpost.co.uk/2012/08/22/farmers-obesity-livestock-antibiotics-_n_1821941.html 1955 study shows antibiotics cause increased weight gain in healthy men: http://jn.nutrition.org/content/56/1/151.full.pdf study shows altered gut flora causes weight gain in mice http://www.nature.com/nature/journal/v488/n7413/full/nature11400.html study shows antibiotics exposure in infancy is linked to higher body mass index later: http://www.nature.com/ijo/journal/vaop/ncurrent/abs/ijo2012132a.html altering gut microbiome directly also alters carbohydrate metabolism and body mass in mice http://www.ncbi.nlm.nih.gov/pubmed/17183312 fecal transplant in obese men alters carbohydrate metabolism, lowers weight http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2705 more info: http://www.nytimes.com/2012/06/19/science/studies-of-human-microbiome-yield-new-insights.html?pagewanted=all gut microbiome: http://www.nature.com/nature/journal/v485/n7398_supp/full/485S12a.html
Views: 4822 thetruthergirls
Human Derived Gut Microbiota Modulates Colonic Secretion in Mice …  – Bhattarai et al. (2017)
 
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Serotonin (5-hydroxytryptamine, 5-HT), an important neurotransmitter and a paracrine messenger in the gastrointestinal (GI) tract, regulates intestinal secretion by its action primarily on 5-HT3 and 5-HT4 receptors. Recent studies highlight the role of gut microbiota in 5-HT biosynthesis. In this study we determine if human-derived gut microbiota affect host secretory response to 5-HT and 5-HT receptor expression. We used proximal colonic mucosa-submucosa preparation from age matched Swiss Webster germ free (GF) and humanized (HM; ex-GF colonized with human gut microbiota) mice. 5-HT evoked a significantly greater increase in short circuit current (ΔIsc) in GF compared to HM mice. (Full article: https://doi.org/10.1152/ajpgi.00448.2016)
Leptin and the neural circuit regulation food intake and glucose metabolism
 
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Leptin and the neural circuit regulation food intake and glucose metabolism Air date: Wednesday, January 11, 2017, 3:00:00 PM Category: WALS - Wednesday Afternoon Lectures Runtime: 00:57:39 Description: NIH Director’s Wednesday Afternoon Lecture Series The discovery of leptin has led to the elucidation of a robust physiologic system that maintains fat stores at a relatively constant level. Leptin is a peptide hormone secreted by adipose tissue in proportion to its mass. This hormone circulates in blood and acts on the hypothalamus to regulate food intake and energy expenditure. When fat mass falls, plasma leptin levels fall stimulating appetite and suppressing energy expenditure until fat mass is restored. When fat mass increases, leptin levels increase, suppressing appetite until weight is lost. By such a mechanism, total energy stores are stably maintained within a relatively narrow range. Recessive mutations in the leptin gene are associated with massive obesity in mice and some humans. Treatment with recombinant leptin markedly reduces food intake and body weight. The low leptin levels in patients with leptin mutations are also associated with multiple abnormalities including infertility, diabetes, and immune abnormalities all of which are corrected by leptin treatment. These findings have established important links between energy stores and many other physiologic systems and led to the use of leptin as a treatment for an increasing number of other human conditions including a subset of obesity, some forms of diabetes including lipodystrophy and hypothalamic amenorrhea, the cessation of menstruation seen in extremely thin women. Identification of a physiologic system that controls energy balance establishes a biologic basis for obesity. Recent studies have explored the relationship between leptin and the reward value of food. In addition, new methods for identifying neurons activated by leptin and other stimuli have been developed as have methods for noninvasively activating cells using radio waves. These new approaches are being applied to studies of the neural processes that control feeding, a complex motivational behavior. For more information go to https://oir.nih.gov/wals Author: Jeffrey Friedman, M.D., Ph.D., Professor, The Rockefeller University; Director, Starr Center for Human Genetics; Investigator, Howard Hughes Medical Institute Permanent link: https://videocast.nih.gov/launch.asp?21075
Views: 8018 nihvcast
Microbiome – How Your Microbiome Impacts Weight Loss
 
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http://www.oursynergyfamily.com/microbiomejudy/ To contact Judy Feldhausen for a free 30 minute consultation, please click on the above link. http://www.oursynergyfamily.com/microbiomedan/ To contact Dan Hammer for a free 30 minute consultation, please click on the above link. We have 3 key questions regarding weight loss. Have you struggled with your weight? Have you tried numerous diets where you've lost weight, but then ended up regaining those pounds and more? Have you given up? If you answered “Yes” to any of these questions, then the answer resides in the makeup of your gut microbiome. While an unhealthy diet, a sedentary lifestyle, and perhaps your genetic makeup can contribute to your battle of the bulge, more and more research is showing that this is not a human genetic issue but rather a microbiome issue. Many times, the foods you crave, have very little to do with want you want. Rather it's your microbiome that's influencing your food choices. How to we know this to be true? Well, the most famous study in this area is the one done on identical human twins. Each twin has the same genetic makeup. However one twin was overweight and the other twin was lean. The researchers then took their human microbiome and injected it into the gut flora of mice so that the microbiome of the mice took on the nature of the human twin. Each recipient mice was given the same diet and daily activities. The results were that the mice with the microbiome from the lean human twin stayed lean. And, the mice with the mircobiome from the overweight human twin gained weight and stored fat. For the overweight twins, their microbial community was dominated by Firmicutes. Whereas, the microbial community of the lean twins were dominated by Bacteroidetes. Unfortunately, there are several common triggers that increase firmicutes over bacterioidetes: Trigger 1 – High intake of omega-6 fatty acids from vegetable oils. Most processed foods use some form of vegetable oil for shelf stability. The problem is these types of omega-6 oils trigger inflammation, which favors the Firmicutes. Trigger 2 – Animal protein creates less diversity in the microbial community, which then allows the Firmicutes to dominate. Trigger 3 – Sugar and processed carbohydrates, like modern-day wheat, are fuel for Firmicutes, which again allows them to dominate your abdominal microbiome. Trigger 4 – Stress triggers the releases of adrenal hormones like cortisol and adrenaline, which lower the Bacterioidetes in your abdominal cavity. To help you started on the right path, Judy and I would like to offer you a 4 step program. Step #1 – Eliminate omega-6 vegetable oils from your diet. Ones like Soybean Oil Canola Oil Vegetable Oil While the food industry, and our government, have tried to convince us that these omega-6 vegetable oils are safe and heart-healthy, they are not. These oils are inflammatory, and help create an environment that allow Firmicutes to flourish, which then creates toxins that your body has to address. Step #2 – Replace the omega-6 vegetable oils with omega 3 healthy fats like Coconut Oil Avocados Grass-fed Butter Fish Rich in Omega 3s Grass-fed Beef Extra-virgin Olive Oil When used in weight management studies, these healthy, anti-inflammatory omega 3 fats create an environment where healthy gut flora can dominate, which lowers inflammation levels, produces significantly less toxins, and increases the probability of weight loss. Step #3 – Eliminate Wheat from your diet. Why are we targeting wheat. Because modern-day wheat has been genetically engineered so that it now has a higher glycemic index that table sugar. It's fuel for firmicutes and a toxin producer. Step #4 – Limit Your Sugar Intake Most of the foods you eat come packaged. With a section on the label for Nutrition Facts. Find it and locate the line that says “Total Carbohydrate” Under this you will see a line that says “Total Sugars” This is the line that you want to pay attention to. Here's what you need to remember: 1 teaspoon of sugar is equal to 4 grams. If you divided the number of grams of sugar by 4 you will determine the number of teaspoons of sugar per serving. Ideally you only want to consume foods that are less than 1 teaspoon or 4 grams of sugar per serving. If you have any questions about this material, then please either email me at [email protected] or call me directly at 630-936-8079. Or you can email Judy at [email protected] or call her directly at 630-289-2750.
Views: 131 Daniel Hammer
Ali Fitness Podcast Episode 013: MICROBIOLOGIST VANESSA RIDAURA
 
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Vanessa Ridaura received her Ph.D. in Molecular Genetics and Genomics from Washington University in St. Louis, specializing in the effect of the microbiome on human health and disease, with a specific focus on the contributions of human gut microbiome to metabolism and obesity. Vanessa went on to become a Post-Doctoral Fellow at the National Institutes of Health in Bethesda, Maryland, studying the microbiome of the skin and its impact on health. Today Vanessa explains the details of her research, discussing how diet and the microbiome work together to influence metabolism. Listen to understand the fundamental science of the microbiota, how diet effects the bacteria in your gut, and current developments in microbiome science. TOPICS COVERED [1:11] Vanessa’s research regarding gut microbiota’s effect on metabolism Microbiota refers to microbes living in epithelial cavities, protect from pathogenic bacteria Germ-free, genetically identical mice colonized with microbiota from twins discordant for obesity On same diet, mice with lean microbiota lost weight while obese gained Given unhealthy human diet of saturated fats, mice gained regardless of microbiota Conclude that components of healthy diet feed beneficial bacteria in gut while unhealthy destroys it [5:58] The ‘battle of microbiota’ Mice eat each other’s feces Hypothesized that obese microbiota would take over Observed opposite in mice on healthy diet (lean microbiota took over) Not the case in context of mice on unhealthy diet Good bacteria + good diet = higher metabolism [9:13] The first fecal transplant proven to work diff develops when antibiotics kill healthy microbiota Fecal microbiome transplants give patient healthy, diverse microbiome to displace C. diff [10:28] What Vanessa learned from her research that has influenced her own diet Little things influence body as whole Simple sugars make easier for bacteria associated with obesity to spread Limit high fat, eat more vegetables No ‘magic bullet’ (must have healthy diet along with lean microbiome) [12:35] The connection between microbiome and type 2 diabetes Healthy animals receiving obese microbiome had increased branched-chain amino acids Early biomarker for type 2 diabetes Develop within two weeks [13:55] Vanessa’s study of the skin microbiome Unlike other microbiome, single species of bacteria can colonize locally on skin and affect immunity Certain species of bacteria increased inflammation (psoriasis, atopic dermatitis) Diet high in saturated fats exacerbated skin disease [17:17] Scientific understanding of the different microbiomes Studied gut for 15-20 years, further ahead Study of skin much newer (only in last five years) Technological advances allow cheap sequencing, mass spectrometry [18:18] How the microbiome of the mouth affects health Periodontitis in pregnant women can cause low infant weight, premature birth Periodontitis also associated with atherosclerosis [19:16] The future of microbiome research Continued work with C. diff Cancer studies (how gut microbiome influences cancer therapy) 10-15 years before see strong intervention studies LEARN MORE ABOUT VANESSA RIDAURA LinkedIn: https://www.linkedin.com/in/vanessa-k-ridaura-ph-d-989516a/ New York Times Article: http://www.nytimes.com/2013/09/06/health/gut-bacteria-from-thin-humans-can-slim-mice-down.html RESOURCES MENTIONED “Cultured Gut Microbiota from Twins Discordant for Obesity Modulate Adiposity and Metabolic Phenotypes in Mice” from Science: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829625/
Views: 29 Ali Fitness
Gut Bacteria, Microbiome Project & Your Metabolism
 
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Download my free video course about gut bacteria and your metabolism here http://bellyfateffect.com/
Views: 5529 Mike Mutzel, MS
Fat Mice Linked to Gut Microbes
 
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Science News reports new research in rodents suggests gut microbes cause obesity by sending messages via the vagus nerve to pack on pounds. In the June 9th issue of Nature magazine, researchers report bacteria in the intestines produce a molecule called acetate, which works through the brain and nervous system to make rats and mice fat. Yale University endocrinologist Gerald Shulman led the study. He said acetate also increases levels of a hunger hormone called ghrelin, which could lead animals and people to eat even more. Biochemist Jonathan Schertzer of McMaster University in Hamilton, Canada, called the paper a “tour-de-force." https://www.sciencenews.org/article/obesity%E2%80%99s-weight-gain-message-starts-gut http://www.wochit.com This video was produced by YT Wochit News using http://wochit.com
Views: 467 Wochit News
HOW STRESS IS RELATED TO GUT MICROBIOTA
 
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REFERENCES Bailey, MT, Dowd, SE, Parry, NMA, Galley, JD, Schauer, DB & Lyte, M 2010, ‘Stressor exposure disrupts commensal microbial populations in the intestines and leads to increased colonization by Citrobacter rodentium’, Infection and Immunity, vol. 78, no. 4, pp. 1509-1519. Bercik, P, Denou, E, Collins, J, Jackson, W, Lu, J, Jury, J, Deng, Y, Blennerhassett, P, Macri, J, McCoy, KD, Verdu, EF & Collins, SM 2011, ‘The intestinal microbiota affect central levels of brain-derived neurotropic factor and behaviour in mice’, Gastroenterology, vol.141, no. 2, pp. 599-609. Carabotti, M, Scirocco, A, Maselli, MA, Severi, C 2015, ‘The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems’, Annals of Gastroenterology : Quarterly Publication of the Hellenic Society of Gastroenterology, vol. 28, no.2, pp.203-209. Foster, JA & Neufeld, KM 2013, ‘Gut-brain axis: how the microbiome influences anxiety and depression’, Trends in Neurosciences, vol. 36, no. 5, pp. 305-312. Foster, J, Rinaman, L and Cryan, J, 2017, ‘Stress & the gut-brain axis: Regulation by the microbiome’, Neurobiology of Stress, pp.1-13. Gunawardene AR, Corfe BM, Staton CA 2011, ‘Classification and functions of enteroendocrine cells of the lower gastrointestinal tract’, International Journal of Experimental Pathology, vol.92, no.4, pp.219-231. Integrative HMP Research Network Consortium 2014, ‘The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health and disease’, Cell Host Microbe, vol. 3. J Clin Invest. 2007;117(1):13-23. doi:10.1172/JCI30227 Moloney, RD, Desbonnet, L, Clarke, G, Dinan, TG & Cryan, JF 2014, ‘The microbiome: stress, health and disease’, Mammalian Genome, vol. 25, no. 1-2, pp. 49-74. O’Mahony, SM, Marhesi, JR, Scully, P, Codling, CC, Ceolho, AM, Quigley, EMM, Cryan, JF & Dinan, TG 2009, ‘Early life stress alters behaviour, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses’, Biological Psychiatry, vol. 65, no. 3, pp. 263-276. Peterson, J, Garges, S, Giovanni, M, McInnes, P, Wang, L, Schloss, J, Bonazzi, V, McEwa, J, Howcroft, T, Karp, R, Lunsford, R, Wellington, C, Belechew, T, Wright, M Giblin, C, David, H, Mills, M, Salomon, R, Mullins, C, Akolkar, B, Begg, L, Davis, C, Grandison, L, Humble, M, Khalsa, J, Little, A, Peavy, H, Pontzer, C, Portney, M, Sayre, M, Starke-Reed, P, Zakhari, S, Read, J, Watson & B, Guyer, M 2009, ‘The NIH Human Microbiome project’, Genome Research, vol. 12, 2317–2323. Rea, K, Dinan, TG & Cryan, JF 2016, ‘The microbiome:a key regulator of stress and neuroinflammation’, Neurobiology of Stress, vol. 4, 23-33. Sudo, N, Chida, Y, Aiba, Y, Sonoda, J, Oyama, N, Yu, X, Kubo, C & Koga, Y 2004, ‘Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice’, The Journal of Physiology, vol. 558, no. 1, pp. 263-275. Edit: reference for image of endocrine cell, J Clin Invest. 2007;117(1):13-23. doi:10.1172/JCI30227
Views: 346 Jackie S
The Diabesity Crisis 2017 - Bottoms up: the gut microbiome and childhood obesity (Wayne Cutfield)
 
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Professor Wayne Cutfield, University of Auckland, presenting 'Bottoms up: the gut microbiome and childhood obesity' at the Diabesity Crisis: How can we make a difference, Friday 17 March 2017, Auckland City Hospital. #diabesityNZ Jointly hosted by Healthier Lives NSC, EDOR, A Better Start NSC Follow us on twitter https://twitter.com/healthierNZ Find out more about the Healthier Lives NSC at https://healthierlives.co.nz/
Being Human | Rob Knight
 
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Whether we’re fat or thin depends on the bacteria in our gut, says biochemist Rob Knight in this video for the World Economic Forum. It’s our microbes, more than our DNA, that makes us who we are: “I can tell you with over 90% accuracy whether you're lean or obese based solely on sequencing your microbial genes,” he says. Knight’s lab at the University of California, San Diego is pioneering global research on microbes, and how they may be linked to a range of conditions from anxiety to autism. Click on the link to watch the full presentation, or read key quotes below. On exploring our inner ecosystem “Each of us consists of about 10 trillion cells that carry our genome that we think of as human, but we have inside us as many as 100 trillion microbial cells - tiny organisms too small to see with the naked eye. And our whole human genome consists of about 20,000 genes, depending on what you count exactly. But our microbial gene catalog ranges from two to 20 million microbial genes, and so by that measure we might think of ourselves as less than one percent human.” “The human microbiome project, which was a huge hundred seventy-three million dollar initiative funded by National Institutes of Health (NIH) to jump-start research on the microbiome, together with a consortium of about 400 other researchers. We mapped the healthy human microbiome and 250 healthy volunteers working at many sites in the body, and the speed with which this escaped the pages of a scientific journals to the cover of Scientific American and then to the cover of The Economist was really dramatic.” On our unique microbial fingerprint “We can prove cause-and-effect by using mice. We can raise mice without any microbes of their own, and then transmit to them the microbes of someone who’s fat versus someone who’s thin; what you see is the amount of weight they gain depends on the microbes they got. Additionally we can do this for behavior: you can make a mouse more anxious by giving it the microbes of a more anxious mouse, or less anxious by giving it the microbes of the less anxious mouse. This is really remarkable in the case of obesity which a lot of people attribute to willpower or to our human genes; or in the case of anxiety because what this shows is that microbes can affect these traits that affect how we think of who we are.” On the potentials of microbial research “One my colleagues at Caltech has done work on a mouse model that resembles some features of autism, where you give pregnant female mice a chemical that simulates a virus, and then their pups have many dysfunctional features that resemble autism. So they have cognitive deficits, they have social deficits, they have got gut barrier dysfunction, and they have compulsive behavior. Part of the reason for this, is that they have a dysfunctional microbial community that is different from the microbial community of a normal mouse.” “You can induce the same symptoms by injecting normal mice with one chemical that this altered microbial community produces, and then you can rescue them by giving them a probiotic, a kind of beneficial bacteria isolated from the human gut. This is model work and we do not yet know how it will apply to humans, but the potential for this kind of research to affect a wide range of diseases that you might not have thought were linked to your gut is tremendous. One remarkable fact about the gut microbiome, is (if you think of it as being like an organ) that is the only organ you can transplant without doing surgery.”
Views: 1714 World Economic Forum
Study: Skin patch that dissolves fat in mice could help treat human obesity
 
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Scientists have made a skin patch that dissolves fat in targeted areas on lab mice. It could be used to treat humans, if further testing reveals it's effective. The study's co-author called it a "noninvasive alternative to liposuction." The patch deploys drugs contained in nanoparticles too small to see. These particles enter the skin through painless microscopic needles. The particles dissolve fat near the patch (and not throughout the body). Scientists tested the patch by applying patches to both si
The microbiota as instructor and arbiter of immune responses in health and disease
 
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The microbiota as instructor and arbiter of immune responses in health and disease Air date: Wednesday, February 22, 2017, 3:00:00 PM Category: WALS - Wednesday Afternoon Lectures Runtime: 01:07:59 Description: NIH Director's Wednesday Afternoon Lecture Series The vertebrate intestinal tract is colonized by hundreds of species of bacteria that outnumber the total cells in the host, yet must be compartmentalized and tolerated to prevent invasive growth and harmful inflammatory responses. A key function of commensal microbes is to contribute to the adaptive immune repertoire and to diverse lymphocyte effector functions. T cell responses against non-invasive commensals contribute to shaping the repertoire of effector/memory and regulatory T cells. How T cells elicited by commensal bacteria can influence autoimmunity is a central question that remains unsolved. The Littman Lab studies the antigenic specificity of microbiota-induced T cells and the mechanisms by which their functions are acquired upon interaction with distinct commensal species. His lab finds that Th17 cells, which are central to mucosal barrier defense but also participate in autoimmune disease, are induced by specific constituents of the microbiota, and acquire effector function only after additional exposure to endogenous adjuvants, such as the serum amyloid A proteins. The lab's studies in mice are not only relevant for human autoimmune diseases, many of which have Th17 cell involvement, but may also provide insights into how commensal microbe-specific T cell responses could be harnessed for mucosal vaccination and cancer immunotherapy. For more information go to https://oir.nih.gov/wals/2016-2017 Author: Dan R. Littman, M.D., Ph.D., Investigator, Howard Hughes Medical Institute; Kimmel Professor of Molecular Immunology at New York University School of Medicine Permanent link: https://videocast.nih.gov/launch.asp?22148
Views: 3719 nihvcast
Microbiomes
 
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A very brief review of microbiomes, and three key studies related to obesity in mice.
Views: 206 BIS 2C- UC Davis
Liping Zhao: Diet, Obesity, and Quality FMT Samples
 
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Dr. Liping Zhao, of Shanghai Jiao Tong University, is at the cutting edge of research on how the gut microbiota influence obesity. Gut Microbiota for Health editors are pleased to bring you a video interview with Dr. Zhao as part of our conference highlights from the 2015 Keystone Symposium, "Gut Microbiota Modulation of Host Physiology: The Search for Mechanism". In this video, Dr. Zhao answers the following questions: - How does dietary change affect the microbiota? - Does microbiota modulation have the potential to treat obesity? - In fecal microbiota transplantation, should the donor have a specific diet before giving a sample? - How can you assess the quality of a fecal microbiota transplantation sample? Learn more at: http://www.gutmicrobiotaforhealth.com/en/evidence-for-bacterial-guilds-in-the-gut-ecosystem/
Podcast #177 - Dr. Grace Liu: Fixing the Gut Microbiome with Resistant Starch and Probiotics
 
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Dr. Grace Liu is renowned for the information she publishes on the blog, Animal Pharm, under the name “Dr. BG”. She is a Food and Nutritional Scientist and Functional Medicine Practitioner with a doctorate in Pharmacology, and one of the most knowledgeable people on the hot button topics of resistant starch (RS) and its effects on the health of the gut microbiome. She uses her expertise in the pharmaceutical world to explore the various scientific, nutritional, and pharmacological ins and outs of optimal health. Why you should listen – Hal comes on Bulletproof Radio to discuss the difference between resistant starch and regular starch, how resistant starch works in the body, how to prioritize the different testing methods for determining gut health, and the things you can do to start fixing your gut immediately. Enjoy the show! For more info & to follow Dr. Grace: Dr. BG Animal Pharm Blog - http://drbganimalpharm.blogspot.com/ The Gut Guardians Podcast – Restore the Flora! - http://restoretheflora.com/podcast-2/ Twitter - @Gut_Goddess - https://twitter.com/Gut_Goddess Resources: The Definitive Guide to Resistant Starch (Mark’s Daily Apple) - http://www.marksdailyapple.com/the-definitive-guide-to-resistant-starch/ Gut bacteria’s fatty acid (butyrate) boosts immune system, reducing inflammation - http://www.medicalnewstoday.com/articles/268786.php Glycemix Index (GI) - http://www.glycemicindex.com/about.php Starch polysaccharides in human nutrition (Critical Reviews in Food Science and Nutrition) - http://www.ncbi.nlm.nih.gov/pubmed/22747080 FODMAPS (Chris Kresser) - http://chriskresser.com/fodmaps-could-common-foods-be-harming-your-digestive-health Intestinal Dysbiosis - http://altmedrev.com/publications/9/2/180.pdf Bacteroides - https://microbewiki.kenyon.edu/index.php/Bacteroides Conjugated linoleic acid for reducing fat mass (American Journal of Clinical Nutrition) - http://ajcn.nutrition.org/content/85/5/1203.full Intestinal microbiota in aged mice is modulated by dietary resistant starch (FEMS Microbiology Ecology) - http://www.ncbi.nlm.nih.gov/pubmed/22909308 uBiome - http://ubiome.com/ Genova 2200 GI Testing - https://www.gdx.net/core/interpretive-guides/GI-Effects-IG.pdf American Gut - http://humanfoodproject.com/americangut/ Gastroesophageal Reflux Disease (GERD) - http://www.nlm.nih.gov/medlineplus/gerd.html Efficacy of increased resistant starch consumption in human type 2 diabetes (Endocrine Connections) - http://www.ncbi.nlm.nih.gov/pubmed/24671124 Yacon syrup: beneficial effects on obesity and insulin resistance in humans (Clinical Nutrition) - http://www.ncbi.nlm.nih.gov/pubmed/19254816 Inulin - http://www.ncbi.nlm.nih.gov/pubmed/24969566 Fructooligosaccharides (Journal of Physiology and Biochemistry) - http://www.ncbi.nlm.nih.gov/pubmed/20119826 Prevotella - https://microbewiki.kenyon.edu/index.php/Prevotella Bifidobacterium - https://microbewiki.kenyon.edu/index.php/Bifidobacterium Oxalic Acid - http://pubchem.ncbi.nlm.nih.gov/compound/oxalic_acid Trypsin inhibitors - http://en.wikipedia.org/wiki/Trypsin_inhibitor Cecum - http://en.wikipedia.org/wiki/Cecum Curcumin - http://www.ncbi.nlm.nih.gov/pubmed/17569205 AMP Kinase (AMPK) - http://en.wikipedia.org/wiki/AMP-activated_protein_kinase Telomeres - http://www4.utsouthwestern.edu/cellbio/shay-wright/intro/facts/sw_facts.html Clostridia - http://www.ncbi.nlm.nih.gov/books/NBK8219/ Betaine HCl - http://amzn.to/1u0mzQD Lactobacillus - http://www.nlm.nih.gov/medlineplus/druginfo/natural/790.html Helicobacter Pylori (Mayo Clinic) - http://www.mayoclinic.org/diseases-conditions/h-pylori/basics/definition/con-20030903 Neurosciences NeuroScreen Essential Neurotransmitter Saliva Test - https://www.neurorelief.com/index.php?p=testDet&testID=238&TestPanelName=NeuroScreen Essential NutrEval FMV Urine Organic Acid Test - https://www.gdx.net/product/nutreval-fm-nutritional-test-blood-urine Akkermansia - http://en.wikipedia.org/wiki/Akkermansia_muciniphila Microflora in centenarians and young subjects (Journal of Clinical Gastroenterology) - http://www.ncbi.nlm.nih.gov/pubmed/22955365 Ox Bile - http://amzn.to/1yofh0s AOR Probiotic-3 - http://amzn.to/1vUySCd Align GI - http://amzn.to/1yxjZbd Garden of Life Primal Defense Ultra - http://amzn.to/1FUqHIA Prescript Assist - http://amzn.to/1FUqAfZ Bulletproof: Uncovering Resistant Starch with Dr. Grace Liu – Podcast #117 - http://bit.ly/1yodubZ Bulletproof Diet Book - http://www.orderbulletproofdietbook.com/ Is there such a thing as Bulletproof Resistant Starch? - http://bit.ly/1vUxu2x The Kale Shake is Awesome – So Upgrade It - http://bit.ly/1rqt2YG Donna Gates on Body Ecology – Podcast #122 - http://bit.ly/12IQl75
Views: 24010 Bulletproof
03 ENG - Human Gut Microbiota - Onset and Shaping through life stages
 
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Moderator: Pr Henry COHEN (Uruguay) Speaker: Pr Luis BUSTOS FERNANDEZ (Argentina) Q&A
Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance
 
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Scientists from the NIH’s National Institute of Diabetes and Digestive and Kidney Diseases led research finding that transferring the gut microbes from wild mice to laboratory mice promoted fitness and significantly improved responses to an otherwise lethal flu virus infection and to colorectal cancer. By making lab mice more closely mirror real-world mice, the approach may improve the odds of success as research moves from mouse to man. The method could also help advance studies in metabolism, behavior, and endocrinology. The results published in Cell: www.cell.com/cell/fulltext/S0092-8674(17)31065-6
Save the Microbes
 
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NYU Langone Medical Center, Lab of Martin Blaser. Humans have co-evolved with the resident microbes that call us "home", known as the microbiota, consisting of trillions of cells that colonize our bodies. The microbiota carry out many beneficial functions, such as producing vitamins, aiding in digestion, and protecting against invading microbes, but disruption from antibiotics or delivery by Caesarian section may have consequences for human health. Recently, antibiotic use has been linked with obesity and asthma. Using both human studies and experimentally observed mice, we are beginning to understand how antibiotics may lead to the disappearance of microbes and to identify key microbes that impact our health.
Views: 7569 NIHOD
Rob Knight: How our microbes make us who we are
 
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Rob Knight is a pioneer in studying human microbes, the community of tiny single-cell organisms living inside our bodies that have a huge — and largely unexplored — role in our health. “The three pounds of microbes that you carry around with you might be more important than every single gene you carry around in your genome,” he says. Find out why. TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more. Find closed captions and translated subtitles in many languages at http://www.ted.com/talks/rob_knight_how_our_microbes_make_us_who_we_are Follow TED news on Twitter: http://www.twitter.com/tednews Like TED on Facebook: https://www.facebook.com/TED Subscribe to our channel: http://www.youtube.com/user/TEDtalksDirector
Views: 219402 TED
USA: OBESITY TREATMENT BREAKTHROUGH
 
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English/Nat It may be too early for the average couch potato to start cheering, but mice looking to lose weight have something new to celebrate. Scientists have created genetically-altered strains of mice that can eat a high-fat diet without gaining weight, which might lead to a new obesity treatment for people. It might look like the big mouse has been overindulging while the little guy has been counting calories. But these two mice have been fed the exact same high-fat diet - the only difference is that the smaller mouse is missing a single gene. According to scientists at the University of Medicine and Dentistry of New Jersey, the missing gene means the mouse cannot store fat. This keeps him looking trim while the genetically normal mouse gets chubby. Professor of Biochemistry, Kiran Chada, says this represents a breakthrough in a new approach to curing obesity. SOUNDBITE: (English) "This mouse, which is normal except for the absence of one gene, the gene that we've been studying, H-M-G-I-C, is resistant to the high fat diet. In other words, it stays at 25 grams. Therefore, the absence of H-M-G-I-C makes mice resistant to diet induced obesity." SUPER CAPTION: Kiran Chada, Department of Biochemistry, University of Medicine and Dentistry of New Jersey The gene in question, H-M-G-I-C, is said to enable the body to store fat. Professor Chada said the question of where the fat goes in the mice without the H-M-G-I-C gene remains a mystery. Chada says while the research on mice is now quite conclusive, it will be quite some time before people can buy an H-M-G-I-C gene inhibitor drug. He estimates it will take up to two years to identify candidates which could block or inhibit the H-M-G-I-C gene in humans - and only then will human trials start. If a promising drug is identified, it will take five to ten years of human tests to achieve the approval of the U-S Food and Drug Administration. But in the end, Chada cautions, there is no simple cure for obesity. SOUNDBITE: (English) "Obesity is a multi-factorial problem. So there's not going to be one magic cure. At the end of the day, I'm afraid that exercise and controlling one's diet will still play a intrinsically important role in controlling obesity." SUPER CAPTION: Kiran Chada, Department of Biochemistry, University of Medicine and Dentistry of New Jersey The study by Professor Chada and his colleague Ashim Anand will be published on April 1 in the journal Nature Genetics. You can license this story through AP Archive: http://www.aparchive.com/metadata/youtube/77af1669d58ba1c9ea3663c56fcc4e23 Find out more about AP Archive: http://www.aparchive.com/HowWeWork
Views: 154 AP Archive
How the Gut Microbiome affects the Brain and Mind
 
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Get 10% off any purchase here: http://squarespace.com/WIL ▲Patreon: https://www.patreon.com/WILearned ▲Twitter: https://twitter.com/jeverettlearned ▲Bitcoin: 1CuSEgDr5raV3XKoHL7W19QRoCkE3iHt1X The gut microbiota is a huge topic and has some very significant implications for health and nutrition. Here I've explained just a tiny bit of the research. A pdf with a transcript for the video and links to sources can be found here: https://www.patreon.com/posts/17115405 ________ Books: "The Good Gut" by Justin and Erica Sonnenburg - http://amzn.to/2ETThV2 "Missing Microbes" By Martin Blaser - http://amzn.to/2Hu43jh "Brain Maker" By David Perlmutter - http://amzn.to/2sF5EiO (Not mentioned in the video, but another good book on the subject) Will have the transcript with links up soon Featured Music: Broke for Free - Meiei Chris Zabriskie - Mario Bava Sleeps in a Little Later than he expected to Broke for Free - Breakfast with Tiffany Chris Zabriskie - Divider Kevin MacLeod - Rollin at 5 For Business inquiries: [email protected]
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